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dc.contributor.authorDu, Bujie
dc.contributor.authorYu, Mengxiao
dc.contributor.authorZheng, Jie
dc.date.accessioned2019-10-25T21:50:23Z
dc.date.available2019-10-25T21:50:23Z
dc.date.created2018-08-03
dc.identifier.issn2058-8437
dc.identifier.urihttps://hdl.handle.net/10735.1/7042
dc.descriptionFull text access from Treasures at UT Dallas is restricted to current UTD affiliates (use the provided Link to Article).
dc.description.abstractKidneys are a major organ for blood filtration and waste elimination and thus play a key role in the transport and clearance of nanoparticles in vivo. The interactions of nanoparticles with different kidney compartments can be precisely regulated by modulating their size, shape and surface chemistry. The quantitative understanding of nanoparticle–kidney interactions at the molecular level is important for improving disease targeting, precisely controlling nanoparticle transport and clearance, and minimizing the potential health hazards of nanomedicines. In this Review, we summarize the glomerular filtration of macromolecules and nanoparticles in the kidney and survey kidney imaging techniques for the study of nanoparticle–kidney interactions ex vivo and in vivo. We investigate the different transport mechanisms of nanoparticles in the kidneys and discuss size, charge and shape dependencies in renal clearance. Nanoparticles are then investigated for the preclinical and clinical detection and treatment of diseases such as kidney dysfunction and cancer. Finally, challenges and opportunities for renal-clearable nanoparticles are highlighted. © 2018, Springer Nature Limited.
dc.description.sponsorshipNational Institutes of Health (NIH R01DK103363 and R43DK116368), the Cancer Prevention and Research Institute of Texas (CPRIT RP140544 and RP160866), and the Welch Research Foundation (AT-1974-20180324).
dc.language.isoen
dc.publisherNature Publishing Group
dc.relation.urihttp://dx.doi.org/10.1038/s41578-018-0038-3
dc.rights©2018
dc.subjectNanomedicine
dc.subjectNanoparticles
dc.subjectKidneys—Diseases
dc.subjectSurface chemistry
dc.subjectBlood—Filtration
dc.subjectGlomerular filtration rate
dc.subjectReview
dc.titleTransport and Interactions of Nanoparticles in the Kidneys
dc.type.genrearticle
dc.description.departmentSchool of Natural Sciences and Mathematics
dc.identifier.bibliographicCitationDu, B., M. Yu, and J. Zheng. 2018. "Transport and interactions of nanoparticles in the kidneys." Nature Reviews Materials 3: 358-374, doi: 10.1038/s41578-018-0038-3
dc.source.journalNature Reviews Materials
dc.identifier.volume3
dc.contributor.utdAuthorDu, Bujie
dc.contributor.utdAuthorYu, Mengxiao
dc.contributor.utdAuthorZheng, Jie


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