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dc.contributor.authorJiang, Xingya
dc.contributor.authorDu, Bujie
dc.contributor.authorTang, Shaoheng
dc.contributor.authorHsieh, J. -T
dc.contributor.authorZheng, Jie
dc.date.accessioned2019-11-08T21:53:20Z
dc.date.available2019-11-08T21:53:20Z
dc.date.created2019-03-27
dc.identifier.issn1433-7851
dc.identifier.urihttps://hdl.handle.net/10735.1/7099
dc.descriptionDue to copyright restrictions full text access from Treasures at UT Dallas is restricted to current UTD affiliates (use the provided Link to Article).
dc.description.abstractNoninvasive monitoring of kidney elimination of engineered nanoparticles at high temporal and spatial resolution will not only significantly advance our fundamental understandings of nephrology on the nanoscale, but also aid in the early detection of kidney disease, which affects more than 10 % of the worldwide population. Taking advantage of strong NIR absorption of the well-defined Au₂₅(SG)₁₈ nanocluster, photoacoustic (PA) imaging was used to visualize its transport in situ through the aorta to the renal parenchyma and its subsequent filtration into the renal pelvis at a temporal resolution down to 1 s. High temporal and spatial resolution imaging of Au₂₅(SG)₁₈ kidney elimination allowed the accurate quantification of the glomerular filtration rate (GFR) of individual kidneys in normal and pathological conditions, broadening the biomedical applications of engineered nanoparticles in preclinical kidney research. © 2019 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim
dc.description.sponsorshipThis work was supported by the NIH (R01DK103363 and R01DK115986), the Welch Research Foundation (AT-1974-20180324), NCI Cancer Center Support Grant (1P30CA142543) and NIH Instrumentation Grant (NIH1S10 OD018094-01A1).
dc.language.isoen
dc.publisherWiley-VCH Verlag
dc.relation.urihttps://dx.doi.org/10.1002/anie.201901525
dc.rights©2019 Wiley‐VCH Verlag GmbH & Co. KGaA, Weinheim
dc.subjectGlomerular filtration rate
dc.subjectNanoparticles
dc.subjectPhotoacoustic imaging
dc.subjectBiomedical engineering
dc.subjectNephrology
dc.subjectKidneys—Diseases
dc.titlePhotoacoustic Imaging of Nanoparticle Transport in the Kidneys at High Temporal Resolution
dc.type.genrearticle
dc.description.departmentSchool of Natural Sciences and Mathematics
dc.identifier.bibliographicCitationJiang, X., B. Du, S. Tang, J. -T Hsieh, et al. 2019. "Photoacoustic Imaging of Nanoparticle Transport in the Kidneys at High Temporal Resolution." Angewandte Chemie - International Edition 58(18): 5994-6000, doi: 10.1002/anie.201901525
dc.source.journalAngewandte Chemie - International Edition
dc.identifier.volume58
dc.identifier.issue18
dc.contributor.utdAuthorJiang, Xingya
dc.contributor.utdAuthorDu, Bujie
dc.contributor.utdAuthorTang, Shaoheng
dc.contributor.utdAuthorZheng, Jie
dc.contributor.VIAF22147423113244881679 (Zheng, J)
dc.contributor.ORCID0000-0001-8546-1882 (Zheng, J)


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