Center for Advanced Pain Studies
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The Center for Advanced Pain Studies is aggressively pursuing lines of research aimed at alleviating suffering from pain and improving the lives of people with chronic pain and/or migraine.
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The Antidiabetic Drug Metformin Prevents and Reverses Neuropathic Pain and Spinal Cord Microglial Activation in Male but not Female Mice
(Academic Press Ltd- Elsevier Science Ltd, 2018-11-01)Metformin is a widely prescribed drug used in the treatment of type II diabetes. While the drug has many mechanisms of action, most of these converge on AMP activated protein kinase (AMPK), which metformin activates. AMPK ... -
Some Prospective Alternatives for Treating Pain: The Endocannabinoid System and its Putative Receptors GPR18 and GPR55
(Frontiers Media SA, 2019-01-08)Background: Marijuana extracts (cannabinoids) have been used for several millennia for pain treatment. Regarding the site of action, cannabinoids are highly promiscuous molecules, but only two cannabinoid receptors (CB₁ ... -
RNA Control in Pain: Blame it on the Messenger
(Blackwell Publishing Ltd, 2019-05-14)mRNA function is meticulously controlled. We provide an overview of the integral role that posttranscriptional controls play in the perception of painful stimuli by sensory neurons. These specialized cells, termed nociceptors, ... -
Transcriptome Analysis of the Human Tibial Nerve Identifies Sexually Dimorphic Expression of Genes Involved in Pain, Inflammation, and Neuro-Immunity
Sex differences in gene expression are important contributors to normal physiology and mechanisms of disease. This is increasingly apparent in understanding and potentially treating chronic pain where molecular mechanisms ...
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