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dc.contributor.authorLiu, L.
dc.contributor.authorYu, Chunxiao
dc.contributor.authorYang, F.
dc.contributor.authorYuan, Z.
dc.contributor.authorWang, Q.
dc.contributor.authorLiu, S.
dc.contributor.authorZuo, C.
dc.contributor.authorGuan, Q.
dc.date.accessioned2020-02-19T22:01:58Z
dc.date.available2020-02-19T22:01:58Z
dc.date.issued2019-04-16
dc.identifier.issn0024-3205
dc.identifier.urihttp://dx.doi.org/10.1016/j.lfs.2019.04.033
dc.identifier.urihttps://hdl.handle.net/10735.1/7283
dc.descriptionDue to copyright restrictions and/or publisher's policy full text access from Treasures at UT Dallas is limited to current UTD affiliates (use the provided Link to Article).
dc.description.abstractAims: Small-for-gestational-age (SGA) fetus is an important public health issue because of its high mortality and long-term effects on health. Maternal hyperuricemia is associated with diverse adverse pregnant outcomes and neonatal disturbance. We aimed to evaluate whether maternal hyper-uric acid (HUA) is associated with the risk of SGA fetus and to explore whether it can modify the association between maternal hyper-blood pressure (HBP) and SGA fetus. Materials and methods: We performed a population-based cross-section retrospective study, a total of 6715 pregnant females were recruited. Multiple logistic regression analysis was performed to identify risk factors significantly correlated with SGA fetus, and then studied the effect of maternal HUA on the association between maternal HBP and SGA fetus. Key findings: We collected 537 SGA fetuses among 6715 pregnant females. Maternal HUA was an independent risk factor for SGA delivery (odds ratio (OR), 2.737; 95% confidence interval (CI), 2.110–3.551). A dose–response association between maternal uric acid and SGA delivery was found among normotensive and hypertensive group. Compared with those whose uric acid was lower than 270 µmo/L with normal–blood pressure (NBP), the risk for SGA delivery in those whose uric acid was higher than 370 µmo/L with stage 2 or 3 hypertension increased 12.695–fold. Significance: Our results suggest that maternal HUA could increase the risk of neonatal SGA, and maternal HUA could be superimposed upon pre-existing maternal HBP and increase the risk for SGA fetus. © 2019 The Authors
dc.description.sponsorship"This work was supported in part by grants from the National Natural Science Foundation of China (81770860, 81471078 and 81641030) and Key Research and Development Plan of Shandong Province, 2016GSF201007."
dc.language.isoen
dc.publisherElsevier Inc.
dc.rights©2019 The Authors
dc.subjectFetus
dc.subjectHypertension
dc.subjectGestational age
dc.subjectUric acid
dc.subjectFetal growth retardation
dc.subjectHyperuricemia
dc.titleMaternal Hyperuricemia Superimposed on Maternal Hypertension Aggravates the Risk of Small-for-Gestational-Age Fetus
dc.type.genrearticle
dc.description.departmentSchool of Natural Sciences and Mathematics
dc.identifier.bibliographicCitationLiu, L., C. Yu, F. Yang, Z. Yuan, et al. 2019. "Maternal hyperuricemia superimposed on maternal hypertension aggravates the risk of small-for-gestational-age fetus." Life Sciences 228: 215-220, doi: 10.1016/j.lfs.2019.04.033
dc.source.journalLife Sciences
dc.identifier.volume228
dc.contributor.utdAuthorYu, Chunxiao


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