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dc.contributor.authorSingh, Jasmine
dc.contributor.authorMoore, William
dc.contributor.authorFattah, Farjana
dc.contributor.authorJiang, Xingya
dc.contributor.authorZheng, Jie
dc.contributor.authorKurian, Pamela
dc.contributor.authorBeg, Muhammad S.
dc.contributor.authorKhan, Saad A.
dc.date.accessioned2020-07-17T15:07:31Z
dc.date.available2020-07-17T15:07:31Z
dc.date.issued2018-12-11
dc.identifier.issn1043-3074
dc.identifier.urihttp://dx.doi.org/10.1002/hed.25492
dc.identifier.urihttps://hdl.handle.net/10735.1/8714
dc.descriptionDue to copyright restrictions and/or publisher's policy full text access from Treasures at UT Dallas is limited to current UTD affiliates (use the provided Link to Article).
dc.description.abstractBackground Silver nanoparticles (AgNP) show efficacy in cancer cell lines. We present the first in-human outcome of AgNP in a cancer patient. Methods Homemade AgNP solution is manufactured using online instructions by a 78-year old male. He started consuming AgNP while on hospice after he developed nasal cavity squamous cell cancer metastatic to liver and lung. Results Electron microscopy of AgNP solution revealed bimodal nanoparticle size distribution: 3 and 12 nm. Inductively coupled plasma mass spectrometry showed basal silver ion concentrations of 32 ng/g, rising to 46 ng/g 1 hour after ingesting 60 mL of AgNP solution. Urine showed no AgNP. No toxicities were observed and he had complete radiographic resolution of his cancer. He remains without evidence of cancer 18 months later. Conclusions AgNP ingestion was associated with sustained radiographic resolution of cancer. Further testing of AgNP should be done to confirm its efficacy in head and neck cancer.
dc.description.sponsorshipCancer Prevention Research Institute of Texas Foundation (grant RP140544)
dc.language.isoen
dc.publisherWiley
dc.rights©2018 Wiley Periodicals, Inc.
dc.subjectHead—Cancer
dc.subjectNanoparticles
dc.subjectSilver
dc.subjectSpontaneous regression
dc.subjectDietary supplements
dc.subjectBreast—Cancer
dc.subjectApoptosis
dc.subjectCancer
dc.subjectOtolaryngology
dc.subjectSurgery
dc.subjectNeck—Cancer
dc.subject.meshHead and Neck Neoplasms
dc.subject.meshNeoplasm Regression, Spontaneous
dc.titleActivity and Pharmacology of Homemade Silver Nanoparticles in Refractory Metastatic Head and Neck Squamous Cell Cancer
dc.type.genrearticle
dc.description.departmentSchool of Natural Sciences and Mathematics
dc.identifier.bibliographicCitationSingh, Jasmine, William Moore, Farjana Fattah, Xingya Jiang, et al. 2019. "Activity and pharmacology of homemade silver nanoparticles in refractory metastatic head and neck squamous cell cancer." Journal for the Sciences and Specialties of the Head and Neck 41(1): E11-E15, doi: 10.1002/hed.25492
dc.source.journalHead and Neck: Journal for the Sciences and Specialties of the Head and Neck
dc.identifier.volume41
dc.identifier.issue1
dc.contributor.utdAuthorJiang, Xingya
dc.contributor.utdAuthorZheng, Jie
dc.contributor.VIAF22147423113244881679 (Zheng, J)
dc.contributor.ORCID0000-0001-8546-1882 (Zheng, J)


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