• Login
    View Item 
    •   Treasures Home
    • Academic Schools and Programs
    • School of Behavioral and Brain Sciences
    • BBS Faculty Research
    • Hart, John
    • View Item
    •   Treasures Home
    • Academic Schools and Programs
    • School of Behavioral and Brain Sciences
    • BBS Faculty Research
    • Hart, John
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Gulf War Illness Associated with Abnormal Auditory P1 Event-Related Potential: Evidence of Impaired Cholinergic Processing Replicated in a National Sample

    Thumbnail
    View/Open
    Link to Article (185.3Kb)
    Date
    2018-11-10
    Author
    Tillman, Gail D.
    Spence, Jeffrey S.
    Briggs, Richard W.
    Haley, Robert W.
    Hart, John
    Kraut, Michael A.
    Metadata
    Show full item record
    Abstract
    Abstract
    Our team previously reported event-related potential (ERP) and hyperarousal patterns from a study of one construction battalion of the U.S. Naval Reserve who served during the 1991 Persian Gulf War. We sought to replicate these findings in a sample that was more representative of the entire Gulf War-era veteran population, including male and female participants from four branches of the military. We collected ERP data from 40 veterans meeting Haley criteria for Gulf War syndromes 1-3 and from 22 matched Gulf War veteran controls while they performed an auditory oddball task. Reports of hyperarousal from the ill veterans were significantly greater than those from the control veterans, and P1 amplitudes in Syndromes 2 and 3 were significantly higher than P1 amplitudes in Syndrome 1, replicating our previous findings. Many of the contributors to the generation of the P1 potential are also involved in the regulation of arousal and are modulated by cholinergic and dopaminergic systems-two systems whose dysfunction has been implicated in Gulf War illness. These differences among the three syndrome groups where their means were on either side of controls is a replication of our previous ERP study and is consistent with previous imaging studies of this population.
    Description
    Due to copyright restrictions and/or publisher's policy full text access from Treasures at UT Dallas is limited to current UTD affiliates (use the provided Link to Article).
    URI
    https://dx.doi.org/10.1016/j.pscychresns.2018.11.006
    https://hdl.handle.net/10735.1/9109
    Collections
    • CBH Research
    • Hart, John

    DSpace software copyright © 2002-2016  DuraSpace
    Contact Us | Send Feedback
    Theme by 
    Atmire NV
     

     

    Browse

    All of TreasuresCommunities & CollectionsBy Issue DateAuthorsTitlesSubjectsThis CollectionBy Issue DateAuthorsTitlesSubjects

    My Account

    Login

    DSpace software copyright © 2002-2016  DuraSpace
    Contact Us | Send Feedback
    Theme by 
    Atmire NV