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dc.contributor.authorTillman, Gail D.
dc.contributor.authorSpence, Jeffrey S.
dc.contributor.authorBriggs, Richard W.
dc.contributor.authorHaley, Robert W.
dc.contributor.authorHart, John
dc.contributor.authorKraut, Michael A.
dc.date.accessioned2020-12-18T20:28:33Z
dc.date.available2020-12-18T20:28:33Z
dc.date.issued2018-11-10
dc.identifier.issn0925-4927
dc.identifier.urihttps://dx.doi.org/10.1016/j.pscychresns.2018.11.006
dc.identifier.urihttps://hdl.handle.net/10735.1/9109
dc.descriptionDue to copyright restrictions and/or publisher's policy full text access from Treasures at UT Dallas is limited to current UTD affiliates (use the provided Link to Article).
dc.description.abstractOur team previously reported event-related potential (ERP) and hyperarousal patterns from a study of one construction battalion of the U.S. Naval Reserve who served during the 1991 Persian Gulf War. We sought to replicate these findings in a sample that was more representative of the entire Gulf War-era veteran population, including male and female participants from four branches of the military. We collected ERP data from 40 veterans meeting Haley criteria for Gulf War syndromes 1-3 and from 22 matched Gulf War veteran controls while they performed an auditory oddball task. Reports of hyperarousal from the ill veterans were significantly greater than those from the control veterans, and P1 amplitudes in Syndromes 2 and 3 were significantly higher than P1 amplitudes in Syndrome 1, replicating our previous findings. Many of the contributors to the generation of the P1 potential are also involved in the regulation of arousal and are modulated by cholinergic and dopaminergic systems-two systems whose dysfunction has been implicated in Gulf War illness. These differences among the three syndrome groups where their means were on either side of controls is a replication of our previous ERP study and is consistent with previous imaging studies of this population.
dc.description.sponsorshipThis study was supported by IDIQ contract VA549-P-0027, awarded and administered by the Department of Veterans Affairs Medical Center, Dallas, TX; U.S. Army Medical Research and Materiel Command grant number DAMD17-01-1-0741; and Grant Number UL1RR024982, titled North and Central Texas Clinical and Translational Science Initiative.
dc.language.isoen
dc.publisherElsevier Ireland Ltd
dc.rights©2018 Elsevier B.V. All rights reserved.
dc.subjectEvoked potentials (Electrophysiology)
dc.subjectDopaminergic neurons
dc.subjectPersian Gulf War, 1991
dc.subjectOperation Desert Shield, 1990-1991
dc.subjectNeurotoxic agents
dc.subjectPost-traumatic stress disorder
dc.subjectChemical weapons
dc.subjectPyridostigmine bromide
dc.subjectSensorimotor integration
dc.subjectVeterans
dc.subjectNeurosciences
dc.subjectPsychiatry
dc.subjectNeurology
dc.subject.meshBasolateral Nuclear Complex
dc.titleGulf War Illness Associated with Abnormal Auditory P1 Event-Related Potential: Evidence of Impaired Cholinergic Processing Replicated in a National Sample
dc.type.genrearticle
dc.description.departmentSchool of Behavioral and Brain Sciences
dc.description.departmentCenter for BrainHealth
dc.identifier.bibliographicCitationTillman, Gail D., Jeffrey S. Spence, Richard W. Briggs, Robert W. Haley, et al. 2019. "Gulf War illness associated with abnormal auditory P1 event-related potential: Evidence of impaired cholinergic processing replicated in a national sample." Psychiatry Research: Neuroimaging 283: 7-15, doi: 10.1016/j.pscychresns.2018.11.006
dc.source.journalPsychiatry Research: Neuroimaging
dc.identifier.volume283
dc.contributor.utdAuthorTillman, Gail D.
dc.contributor.utdAuthorHart, John, Jr.


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