Synaptosomal Mitochondrial Dysfunction In 5xFAD Mouse Model of Alzheimer's Disease

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dc.contributor.Scopus24824108100 (Du. H)en_US
dc.contributor.authorWang, Luen_US
dc.contributor.authorGuo, Lanen_US
dc.contributor.authorLu, Linen_US
dc.contributor.authorSun, Huilien_US
dc.contributor.authorShao, Mumingen_US
dc.contributor.authorBeck, Simon J.en_US
dc.contributor.authorLi, Linen_US
dc.contributor.authorRamachandran, Jananien_US
dc.contributor.authorDu, Yifengen_US
dc.contributor.authorDu, Hengen_US
dc.contributor.utdAuthorWang, Luen_US
dc.contributor.utdAuthorGuo, Lanen_US
dc.contributor.utdAuthorLu, Linen_US
dc.contributor.utdAuthorSun, Huilien_US
dc.contributor.utdAuthorBeck, Simon J.en_US
dc.contributor.utdAuthorLi, Linen_US
dc.contributor.utdAuthorRamachandran, Jananien_US
dc.contributor.utdAuthorDu, Hengen_US
dc.date.accessioned2018-06-01T16:42:13Z
dc.date.available2018-06-01T16:42:13Z
dc.date.created2016-03-04en_US
dc.date.issued2018-06-01
dc.description.abstractBrain mitochondrial dysfunction is hallmark pathology of Alzheimer’s disease (AD). Recently, the role of synaptosomal mitochondrial dysfunction in the development of synaptic injury in AD has received increasing attention. Synaptosomal mitochondria are a subgroup of neuronal mitochondria specifically locating at synapses. They play an essential role in fueling synaptic functions by providing energy on the site; and their defects may lead to synaptic failure, which is an early and pronounced pathology in AD. In our previous studies we have determined early synaptosomal mitochondrial dysfunction in an AD animal model (J20 line) overexpressing human Amyloid beta (Aβ), the key mediator of AD. In view of the limitations of J20 line mice in representing the full aspects of amyloidopathy in AD cases, we employed 5xFAD mice which are thought to be a desirable paradigm of amyloidopathy as seen in AD subjects. In addition, we have also examined the status of synaptosomal mitochondrial dynamics as well as Parkin-mediated mitophagy which have not been previously investigated in this mouse model. In comparison to nontransgenic (nonTg mice), 5xFAD mice demonstrated prominent synaptosomal mitochondrial dysfunction. Moreover, synaptosomal mitochondria from the AD mouse model displayed imbalanced mitochondrial dynamics towards fission along with activated Parkin and LC3BII recruitment correlating to spatial learning and memory impairments in 5xFAD mice in an age-dependent manner. These results suggest that synaptosomal mitochondrial deficits are primary pathology in Aβ-rich environments and further confirm the relevance of synaptosomal mitochondrial deficits to the development of AD.en_US
dc.description.sponsorshipNIH (R00AG037716); Alzheimer’s Association (NIRG-12-242803); NSFC (131271145, 1381200847) and SDNSF (JQ201318)en_US
dc.identifier.bibliographicCitationWang, Lu, Lan Guo, Lin Lu, Huili Sun, et al. 2016. "Synaptosomal Mitochondrial Dysfunction in 5xFAD Mouse Model of Alzheimer's Disease." PLOS One 11(3), doi:10.1371/journal.pone.0150441en_US
dc.identifier.issn1932-6203en_US
dc.identifier.issue3en_US
dc.identifier.urihttp://hdl.handle.net/10735.1/5826
dc.identifier.volume11en_US
dc.relation.urihttp://dx.doi.org/10.1371/journal.pone.0150441
dc.rightsCC BY 4.0 (Attribution)en_US
dc.rights©2016 The Authors.en_US
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en_US
dc.sourcePLOS One
dc.subjectMitochondriaen_US
dc.subjectAlzheimer's Diseaseen_US
dc.subjectNeuronsen_US
dc.subjectStains and staining (Microscopy)en_US
dc.subjectCognition disordersen_US
dc.subjectLearning abilityen_US
dc.subjectMemory disorders in old ageen_US
dc.subjectSynaptosomesen_US
dc.subjectSynapsesen_US
dc.subjectAmyloid beta-proteinen_US
dc.subject5xFAD miceen_US
dc.subjectMitochondrial Degradationen_US
dc.subjectParkin proteinen_US
dc.titleSynaptosomal Mitochondrial Dysfunction In 5xFAD Mouse Model of Alzheimer's Diseaseen_US
dc.type.genrearticleen_US

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