Modulation of Oscillatory Power and Connectivity in the Human Posterior Cingulate Cortex Supports the Encoding and Retrieval of Episodic Memories

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dc.contributor.authorLega, Bradleyen_US
dc.contributor.authorGermi, Jamesen_US
dc.contributor.authorRugg, Michael D.en_US
dc.contributor.utdAuthorRugg, Michael D.en_US
dc.date.accessioned2018-08-24T21:23:58Z
dc.date.available2018-08-24T21:23:58Z
dc.date.created2017-08
dc.descriptionFull text access from Treasures at UT Dallas is available only to current UTD affiliates.en_US
dc.description.abstractExisting data from noninvasive studies have led researchers to posit that the posterior cingulate cortex (PCC) supports mnemonic processes: It exhibits degeneration in memory disorders, and fMRI investigations have demonstrated memory-related activation principally during the retrieval of memory items. Despite these data, the role of the PCC in episodic memory has received only limited treatment using the spatial and temporal precision of intracranial EEG, with previous analyses focused on item retrieval. Using data gathered from 21 human participants who underwent stereo-EEG for seizure localization, we characterized oscillatory patterns in the PCC during the encoding and retrieval of episodic memories. We identified a subsequent memory effect during item encoding characterized by increased gamma band oscillatory power and a low-frequency power desynchronization. Fourteen participants had stereotactic electrodes located simultaneously in the hippocampus and PCC, and with these unique data, we describe connectivity changes between these structures that predict successful item encoding and that precede item retrieval. Oscillatory power during retrieval matched the pattern we observed during encoding, with low-frequency (below 15 Hz) desynchronization and a gamma band (especially high gamma, 70-180 Hz) power increase. Encoding is characterized by synchrony between the hippocampus and PCC, centered at 3 Hz, consistent with other observations of properties of this oscillation akin to those for rodent theta activity. We discuss our findings in light of existing theories of episodic memory processing, including the information via desynchronization hypothesis and retrieved context theory, and examine how our data fit with existing theories for the functional role of the PCC. These include a postulated role for the PCC in modulating internally directed attention and for representing or integrating contextual information for memory items.en_US
dc.description.sponsorshipUniversity of Texas Brain Seed grant no. 366582en_US
dc.identifier.bibliographicCitationLega, Bradley, James Germi, and Michael Rugg. 2017. "Modulation of Oscillatory Power and Connectivity in the Human Posterior Cingulate Cortex Supports the Encoding and Retrieval of Episodic Memories." Journal of Cognitive Neuroscience 29(8), doi: 10.1162/jocn_a_01133en_US
dc.identifier.issn0898-929Xen_US
dc.identifier.issue8en_US
dc.identifier.urihttp://hdl.handle.net/10735.1/6030
dc.identifier.volume29en_US
dc.language.isoenen_US
dc.publisherMIT Pressen_US
dc.relation.urihttp://dx.doi.org/10.1162/jocn_a_01133en_US
dc.rights©2017 Massachusetts Institute of Technologyen_US
dc.source.journalJournal of Cognitive Neuroscienceen_US
dc.subjectParietal Lobeen_US
dc.subjectElectroencephalography Phase Synchronizationen_US
dc.subjectHippocampus (Brain)en_US
dc.subjectOscillationsen_US
dc.subjectMagnetic Resonance Imagingen_US
dc.subjectGyrus Cingulien_US
dc.subjectEpisodic memoryen_US
dc.titleModulation of Oscillatory Power and Connectivity in the Human Posterior Cingulate Cortex Supports the Encoding and Retrieval of Episodic Memoriesen_US
dc.typeTexten_US
dc.type.genrearticleen_US

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