Neural effects of positive and negative incentives during marijuana withdrawal

dc.contributor.authorFilbey, Francesca M.en_US
dc.contributor.authorDunlop, Josephen_US
dc.contributor.authorMyers, Ursula S.en_US
dc.date.accessioned2014-07-16T20:03:46Z
dc.date.available2014-07-16T20:03:46Z
dc.date.created2013-05-15
dc.description.abstractIn spite of evidence suggesting two possible mechanisms related to drug-seeking behavior, namely reward-seeking and harm avoidance, much of the addiction literature has focused largely on positive incentivization mechanisms associated with addiction. In this study, we examined the contributing neural mechanisms of avoidance of an aversive state to drug-seeking behavior during marijuana withdrawal. To that end, marijuana users were scanned while performing the monetary incentive delay task in order to assess positive and negative incentive processes. The results showed a group x incentive interaction, such that marijuana users had greater response in areas that underlie reward processes during positive incentives while controls showed greater response in the same areas, but to negative incentives. Furthermore, a negative correlation between withdrawal symptoms and response in the amygdala during negative incentives was found in the marijuana users. These findings suggest that although marijuana users have greater reward sensitivity and less harm avoidance than controls, that attenuated amygdala response, an area that underlies fear and avoidance, was present in marijuana users with greater marijuana withdrawal symptoms. This is concordant with models of drug addiction that involve multiple sources of reinforcement in substance use disorders, and suggests the importance of strategies that focus on respective mechanisms.en_US
dc.description.sponsorship"This research was funded by a National Institute on Drug Abuse/National Institutes of Health grant: #KO1 DA021632 to Francesca Filbey. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript."en_US
dc.identifier.bibliographicCitationFilbey, Francesca M., Joseph Dunlop, and Ursula S. Myers. 2013. "Neural effects of positive and negative incentives during marijuana withdrawal." PLOS One 8(5): e61470.en_US
dc.identifier.issn1932-6203en_US
dc.identifier.issue5en_US
dc.identifier.urihttp://hdl.handle.net/10735.1/3693
dc.identifier.volume8en_US
dc.relation.urihttp://dx.doi.org/10.1371/journal.pone.0061470en_US
dc.rightsCC BY 3.0 (Attribution)en_US
dc.rights©2013 The Authors.en_US
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/en_US
dc.source.journalPLOS Oneen_US
dc.subjectMarijuanaen_US
dc.subjectDrug withdrawal symptomsen_US
dc.subjectAmygdalaen_US
dc.subjectDrug addictionen_US
dc.titleNeural effects of positive and negative incentives during marijuana withdrawalen_US
dc.typeTexten_US
dc.type.genrearticleen_US

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