Assessment of Unconstrained Cerebrovascular Reactivity Marker for Large Age-Range fMRI Studies

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dc.contributor.authorKannurpatti, S. S.en_US
dc.contributor.authorMotes, Michael A.en_US
dc.contributor.authorBiswal, B. B.en_US
dc.contributor.authorRypma, Barten_US
dc.date.accessioned2014-10-06T21:29:34Z
dc.date.available2014-10-06T21:29:34Z
dc.date.created2014-02-13
dc.description.abstractBreath hold (BH), a commonly used task to measure cerebrovascular reactivity (CVR) in fMRI studies varies in outcome among individuals due to subject-physiology and/or BH-inspiration/expiration differences (i.e., performance). In prior age-related fMRI studies, smaller task-related BOLD response variability is observed among younger than older individuals. Also, a linear CVR versus task relationship exists in younger individuals which maybe useful to test the accuracy of CVR responses in older groups. Hence we hypothesized that subject-related physiological and/or BH differences, if present, may compromise CVR versus task linearity in older individuals. To test the hypothesis, empirical BH versus task relationships from motor and cognitive areas were obtained in younger (mean age = 26 years) and older (mean age = 58 years) human subjects. BH versus task linearity was observed only in the younger group, confirming our hypothesis. Further analysis indicated BH responses and its variability to be similar in both younger and older groups, suggesting that BH may not accurately represent CVR in a large age range. Using the resting state fluctuation of amplitude (RSFA) as an unconstrained alternative to BH, subject-wise correspondence between BH and RSFA was tested. Correlation between BH versus RSFA was significant within the motor but was not significant in the cognitive areas in the younger and was completely disrupted in both areas in the older subjects indicating that BH responses are constrained by subject-related physiology and/or performance-related differences. Contrasting BH to task, RSFA-task relationships were independent of age accompanied by age-related increases in CVR variability as measured by RSFA, not observed with BH. Together the results obtained indicate that RSFA accurately represents CVR in any age range avoiding multiple and yet unknown physiologic and task-related pitfalls of BH.en_US
dc.description.sponsorshipUS National Institutes of Health grants AG029523-02 (BR) and AG032088-02 (BB) and American Heart Association grant 0930132N (SK)en_US
dc.identifier.bibliographicCitationKannurpatti, S. S., M. A. Motes, B. B. Biswal, and B. Rypma. 2014. "Assessment of unconstrained cerebrovascular reactivity marker for large age-range fMRI studies." PLOS One 9(2).en_US
dc.identifier.issn1932-6203en_US
dc.identifier.issue2en_US
dc.identifier.urihttp://hdl.handle.net/10735.1/4085
dc.identifier.volume9en_US
dc.publisherPublic Library of Scienceen_US
dc.relation.urihttp://dx.doi.org/10.1371/journal.pone.0088751en_US
dc.rightsCC BY 4.0 (Attribution)en_US
dc.rights©2014 The Authors.en_US
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en_US
dc.source.journalPLOS Oneen_US
dc.subjectBreath holden_US
dc.subjectMagnetic Resonance Imagingen_US
dc.subjectCerebrovascular reactivityen_US
dc.subjectResting State Fluctuation of Amplitudeen_US
dc.subjectMotor Skillsen_US
dc.subjectCognitive Skillsen_US
dc.titleAssessment of Unconstrained Cerebrovascular Reactivity Marker for Large Age-Range fMRI Studiesen_US
dc.typeTexten_US
dc.typetext
dc.type.genrearticleen_US

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