Nanomechanical Imaging of Soft Samples in Liquid Using Atomic Force Microscopy

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dc.contributor.authorMinary-Jolandan, Majiden_US
dc.contributor.authorYu, M. -Fen_US
dc.date.accessioned2014-08-14T20:38:45Z
dc.date.available2014-08-14T20:38:45Z
dc.date.created2013-10-04en_US
dc.description.abstractThe widely used dynamic mode atomic force microscopy (AFM) suffers severe sensitivity degradation and noise increase when operated in liquid. The large hydrodynamic drag between the oscillating AFM cantilever and the surrounding liquid overwhelms the dissipative tip-sample interaction forces that are employed for nanomechanical imaging. In this article, we show that the recently developed Trolling-Mode AFM based on a nanoneedle probe can resolve nanomechanical properties on soft samples in liquid, enabled by the significantly reduced hydrodynamic drag between the cantilever and the liquid. The performance of the method was demonstrated by mapping mechanical properties of the membrane of living HeLa cells.en_US
dc.description.sponsorshipNSF Grant Nos. CMMI-0726878 and CBET-0731096en_US
dc.identifier.citationMinary-Jolandan, M. @., and M. -F Yu. 2013. "Nanomechanical imaging of soft samples in liquid using atomic force microscopy." Journal of Applied Physics 114(134313): 1-6.en_US
dc.identifier.issn0021-8979en_US
dc.identifier.issue134313en_US
dc.identifier.urihttp://hdl.handle.net/10735.1/3879
dc.identifier.volume114en_US
dc.language.isoenen_US
dc.relation.urihttp://dx.doi.org/10.1063/1.4824080en_US
dc.rights©2013 AIP Publishing LLCen_US
dc.rights.holder©2013 AIP Publishing LLCen_US
dc.source.journalJournal of Applied Physicsen_US
dc.subjectNanoneedlesen_US
dc.subjectAtomic force microscopyen_US
dc.subjectHydrodynamicsen_US
dc.subjectLiquids--Surfacesen_US
dc.subjectImaging systems in medicineen_US
dc.titleNanomechanical Imaging of Soft Samples in Liquid Using Atomic Force Microscopyen_US
dc.type.genrearticleen_US

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