Basolateral Amygdala Inputs to the Medial Entorhinal Cortex Selectively Modulate the Consolidation of Spatial and Contextual Learning

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dc.contributor.authorWahlstrom, Krista L.
dc.contributor.authorHuff, Mary L.
dc.contributor.authorEmmons, Eric B.
dc.contributor.authorFreeman, John H.
dc.contributor.authorNarayanan, Nandakumar S.
dc.contributor.authorMcIntyre, Christa K.
dc.contributor.authorLaLumiere, Ryan T.
dc.contributor.utdAuthorMcIntyre, Christa K.
dc.date.accessioned2019-05-31T19:55:10Z
dc.date.available2019-05-31T19:55:10Z
dc.date.created2018-03-14
dc.description.abstractAlthough evidence suggests that the basolateral amygdala (BLA) and dorsal hippocampus (DH) work together to influence the consolidation of spatial/contextual learning, the circuit mechanism by which the BLA selectively modulates spatial/contextual memory consolidation is not clear. The medial entorhinal cortex (mEC) is a critical region in the hippocampus-based system for processing spatial information. As an efferent target of the BLA, the mEC is a candidate by which the BLA influences the consolidation of such learning. To address several questions regarding this issue, male Sprague Dawley rats received optogenetic manipulations of different BLA afferents immediately after training in different learning tasks. Optogenetic stimulation of the BLA-mEC pathway using ChR2(E123A) after spatial and cued-response Barnes maze training enhanced and impaired retention, respectively, whereas optical inhibition of the pathway using eNpHR3.0 produced trends in the opposite direction. Similar stimulation of the BLA-posterior dorsal striatum pathway had no effect. BLA-mEC stimulation also selectively enhanced retention for the contextual, but not foot shock, component of a modified contextual fear-conditioning procedure. In both sets of experiments, only stimulation using bursts of 8 Hz light pulses significantly enhanced retention, suggesting the importance of driving activity in this frequency range. An 8 Hz stimulation of the BLA- mEC pathway increased local field potential power in the same frequency range in the mEC and in the DH. Together, the present findings suggest that the BLA modulates the consolidation of spatial/contextual memory via projections to the mEC and that activity within the 8 Hz range is critical for this modulation.
dc.description.departmentSchool of Behavioral and Brain Sciences
dc.description.sponsorshipThis work was supported by the National Institutes of Health Grants (MH105187; NS089470; NS088567: MH104384).
dc.identifier.bibliographicCitationWahlstrom, Krista L., Mary L. Huff, Eric B. Emmons, John H. Freeman, et al. 2018. "Basolateral Amygdala Inputs to the Medial Entorhinal Cortex Selectively Modulate the Consolidation of Spatial and Contextual Learning." Journal of Neuroscience 38(11): 2698-2712, doi:10.1523/JNEUROSCI.2848-17.2018
dc.identifier.issn0270-6474
dc.identifier.issue11
dc.identifier.urihttps://hdl.handle.net/10735.1/6516
dc.identifier.volume38
dc.language.isoen
dc.publisherSoc Neuroscience
dc.relation.urihttp://dx.doi.org/10.1523/JNEUROSCI.2848-17.2018
dc.rightsCC BY 4.0 (Attribution)
dc.rights©2018 The Authors
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.source.journalJournal of Neuroscience
dc.subjectHippocampus
dc.subjectMemory
dc.subjectRecognition (Psychology)
dc.subjectCaudate Nucleus
dc.subjectDissociation
dc.subjectCorpus Striatum
dc.subjectFrontal Lobe
dc.subjectOptogenetics
dc.subjectTheta rhythm
dc.titleBasolateral Amygdala Inputs to the Medial Entorhinal Cortex Selectively Modulate the Consolidation of Spatial and Contextual Learning
dc.type.genrearticle

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