A New Paradigm in Sweat Based Wearable Diagnostics Biosensors using Room Temperature Ionic Liquids (RTILs)

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dc.contributor.authorMunjie, Rujuta D.en_US
dc.contributor.authorMuthukumar, Sriramen_US
dc.contributor.authorJagannath, Badrinathen_US
dc.contributor.authorPrasad, Shalinien_US
dc.contributor.utdAuthorMunjie, Rujuta D.en_US
dc.contributor.utdAuthorJagannath, Badrinathen_US
dc.contributor.utdAuthorPrasad, Shalinien_US
dc.creatorErik Jonsson School of Engineering and Computer Scienceen_US
dc.date.accessioned2018-05-07T21:46:46Z
dc.date.available2018-05-07T21:46:46Z
dc.date.created2017-05-16en_US
dc.date.issued2018-05-07
dc.descriptionIncludes supplementary material. This paper was recognized by the publisher as being one of the ten most read chemistry papers appearing in Scientific Reports in 2017.en_US
dc.description.abstractSuccessful commercialization of wearable diagnostic sensors necessitates stability in detection of analytes over prolonged and continuous exposure to sweat. Challenges are primarily in ensuring target disease specific small analytes (i.e. metabolites, proteins, etc.) stability in complex sweat buffer with varying pH levels and composition over time. We present a facile approach to address these challenges using RTILs with antibody functionalized sensors on nanoporous, flexible polymer membranes. Temporal studies were performed using both infrared spectroscopic, dynamic light scattering, and impedimetric spectroscopy to demonstrate stability in detection of analytes, Interleukin-6 (IL-6) and Cortisol, from human sweat in RTILs. Temporal stability in sensor performance was performed as follows: (a) detection of target analytes after 0, 24, 48, 96, and 168 hours post-antibody sensor functionalization; and (b) continuous detection of target analytes post-antibody sensor functionalization. Limit of detection of IL-6 in human sweat was 0.2 pg/mL for 0–24 hours and 2 pg/mL for 24–48 hours post-antibody sensor functionalization. Continuous detection of IL-6 over 0.2–200 pg/mL in human sweat was demonstrated for a period of 10 hours post-antibody sensor functionalization. Furthermore, combinatorial detection of IL-6 and Cortisol in human sweat was established with minimal cross-talk for 0–48 hours post-antibody sensor functionalization.en_US
dc.identifier.bibliographicCitationMunjie, R. D., S. Muthuhumar, B. Jagannath, et al. 2017. "A new paradigm in sweat based wearable diagnostics biosensors using room temperature ionic liquids (RTILs)" Scientific Reports 7(1), doi:10.1038/s41598-017-02133-0en_US
dc.identifier.issn2045-2322en_US
dc.identifier.issue1en_US
dc.identifier.urihttp://hdl.handle.net/10735.1/5704
dc.identifier.volume7en_US
dc.language.isoenen_US
dc.publisherSpringer Natureen_US
dc.relation.urihttp://dx.doi.org/10.1038/s41598-017-02133-0en_US
dc.rightsCC BY 4.0 (Attribution)en_US
dc.rights©2017 The Authors.en_US
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en_US
dc.source.journalScientific Reportsen_US
dc.subjectBiomedical Engineeringen_US
dc.subjectSweaten_US
dc.subjectWearable Electronic Devicesen_US
dc.subjectHydrocortisoneen_US
dc.subjectInterleukin-6en_US
dc.titleA New Paradigm in Sweat Based Wearable Diagnostics Biosensors using Room Temperature Ionic Liquids (RTILs)en_US
dc.type.genrearticleen_US

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