Polymeric Encapsulation of Vaccines for Enhanced Immunogenicity
| dc.contributor.advisor | Gassensmith, Jeremiah J | |
| dc.contributor.advisor | Izen, Joseph | |
| dc.contributor.committeeMember | D'Arcy, Sheena | |
| dc.contributor.committeeMember | Meloni, Gabriele | |
| dc.contributor.committeeMember | Zheng, Jie | |
| dc.creator | Brohlin, Olivia Rose | |
| dc.date.accessioned | 2024-08-30T15:49:03Z | |
| dc.date.available | 2024-08-30T15:49:03Z | |
| dc.date.created | 2022-05 | |
| dc.date.issued | 2022-05 | |
| dc.date.submitted | May 2022 | |
| dc.date.updated | 2024-08-30T15:49:03Z | |
| dc.description.abstract | Vaccines have been used for hundreds of years to provide protection against infectious diseases. Early vaccine formulations provided strong protection as they were highly immunogenic but were hindered by harsh associated side effects. In an attempt to improve the safety profiles of vaccines, isolated components of pathogens were used instead of live-attenuated or whole-cell formulations. These subunit vaccines were much more tolerable but were unfortunately less effective at providing protection. To overcome this, several methods to adjuvant vaccines have been investigated. One method is to improve cellular uptake of subunit antigens by the components of the innate immune system, specifically antigen presenting cells (APCs) whereas another is to prolong exposure of the antigen to the immune system via an antigen depot. Both of these mechanisms have been effective in inducing long-lasting immunity via activation of T-cells and B-cells. Herein a class of polymeric scaffolds, metal-organic frameworks (MOFs), have been employed to improve both APC uptake of model vaccines and provide an antigen depot. This has been shown to improve the immunogenicity of immunoadjuvants, subunit antigens, and wholecell vaccines. | |
| dc.format.mimetype | application/pdf | |
| dc.identifier.uri | ||
| dc.identifier.uri | https://hdl.handle.net/10735.1/10106 | |
| dc.language.iso | en | |
| dc.subject | Chemistry, Biochemistry | |
| dc.title | Polymeric Encapsulation of Vaccines for Enhanced Immunogenicity | |
| dc.type | Thesis | |
| dc.type.material | text | |
| local.embargo.lift | 2024-05-01 | |
| local.embargo.terms | 2024-05-01 | |
| thesis.degree.college | School of Natural Sciences and Mathematics | |
| thesis.degree.department | Chemistry | |
| thesis.degree.grantor | The University of Texas at Dallas | |
| thesis.degree.name | PHD |