Speech Sound Processing Deficits and Training-Induced Neural Plasticity in Rats with Dyslexia Gene Knockdown

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dc.contributor.ISNI0000 0001 3852 473X (Kilgard, MP)
dc.contributor.ISNI0000 0001 2879 2132 (Rennaker, RL)
dc.contributor.authorCentanni, Tracy M.en_US
dc.contributor.authorChen, Fuyien_US
dc.contributor.authorBooker, Anne M.en_US
dc.contributor.authorEngineer, Crystal T.en_US
dc.contributor.authorSloan, Andrew M.en_US
dc.contributor.authorRennaker, Robert L.en_US
dc.contributor.authorLoTurco, Joseph J.en_US
dc.contributor.authorKilgard, Michael P.en_US
dc.date.accessioned2014-09-10T20:09:57Z
dc.date.available2014-09-10T20:09:57Z
dc.date.created2014-05-28
dc.description.abstractIn utero RNAi of the dyslexia-associated gene Kiaa0319 in rats (KIA-) degrades cortical responses to speech sounds and increases trial-by-trial variability in onset latency. We tested the hypothesis that KIA- rats would be impaired at speech sound discrimination. KIA- rats needed twice as much training in quiet conditions to perform at control levels and remained impaired at several speech tasks. Focused training using truncated speech sounds was able to normalize speech discrimination in quiet and background noise conditions. Training also normalized trial-by-trial neural variability and temporal phase locking. Cortical activity from speech trained KIA- rats was sufficient to accurately discriminate between similar consonant sounds. These results provide the first direct evidence that assumed reduced expression of the dyslexia-associated gene KIAA0319 can cause phoneme processing impairments similar to those seen in dyslexia and that intensive behavioral therapy can eliminate these impairments. ;en_US
dc.description.sponsorshipNational Institute on Deafness and Other Communication Disorders (R01DC010433); National Institute of Child Health and Human Development (HD055655)en_US
dc.identifier.bibliographicCitationCentanni, Tracy M., Fuyi Chen, Anne M. Booker, Crystal T. Engineer, et al. 2014. "Speech sound processing deficits and training-induced neural plasticity in rats with dyslexia gene knockdown." PLOS One 9(5): e98439.en_US
dc.identifier.issn1932-6203en_US
dc.identifier.issue5en_US
dc.identifier.startpage98439en_US
dc.identifier.urihttp://hdl.handle.net/10735.1/3999
dc.identifier.volume9en_US
dc.publisherPublic Library of Scienceen_US
dc.relation.urihttp://dx.doi.org/10.1371/journal.pone.0098439en_US
dc.rightsCC BY 4.0 (Attribution)en_US
dc.rights©2014 The Authorsen_US
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en_US
dc.source.journalPLOS Oneen_US
dc.subjectRatsen_US
dc.subjectSpeechen_US
dc.subjectDyslexia--Researchen_US
dc.subjectKIAA0319 protein, raten_US
dc.subjectPosterior auditory fields (PAF)en_US
dc.titleSpeech Sound Processing Deficits and Training-Induced Neural Plasticity in Rats with Dyslexia Gene Knockdownen_US
dc.typeTexten_US
dc.type.genrearticleen_US

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Kilgard, Michael P.
BBS Staff and Student Research
Rennaker, Robert L.