Altered Amygdala Connectivity in Individuals with Chronic Traumatic Brain Injury and Comorbid Depressive Symptoms

Simple item page
dc.contributor.ISNI0000 0003 5170 3614 (Chapman, SB)
dc.contributor.ORCID0000-0002-4574-7306 (Han, K)en_US
dc.contributor.authorHan, Kihwanen_US
dc.contributor.authorChapman, Sandra Bonden_US
dc.contributor.authorKrawczyk, Daniel C.en_US
dc.contributor.utdAuthorHan, Kihwanen_US
dc.contributor.utdAuthorChapman, Sandra Bonden_US
dc.contributor.utdAuthorKrawczyk, Daniel C.en_US
dc.date.accessioned2016-03-28T18:59:18Z
dc.date.available2016-03-28T18:59:18Z
dc.date.created2015-11-04
dc.description.abstractDepression is one of the most common psychiatric conditions in individuals with chronic traumatic brain injury (TBI). Though depression has detrimental effects in TBI and network dysfunction is a "hallmark" of TBI and depression, there have not been any prior investigations of connectivity-based neuroimaging biomarkers for comorbid depression in TBI. We utilized resting-state functional magnetic resonance imaging to identify altered amygdala connectivity in individuals with chronic TBI (8 years post injury on average) exhibiting comorbid depressive symptoms (N = 31), relative to chronic TBI individuals having minimal depressive symptoms (N = 23). Connectivity analysis of these participant sub-groups revealed that the TBI-plus-depressive symptoms group showed relative increases in amygdala connectivity primarily in the regions that are part of the salience, somatomotor, dorsal attention, and visual networks P(voxel) < 0.01, P(cluster) < 0.025). Relative increases in amygdala connectivity in the TBI-plus-depressive symptoms group were also observed within areas of the limbic cortical mood regulating circuit (the left dorsomedial and right dorsolateral prefrontal cortices and thalamus) and the brainstem. Further analysis revealed that spatially dissociable patterns of correlation between amygdala connectivity and symptom severity according to subtypes (Cognitive and Affective) of depressive symptoms (p(voxel) < 0.01, p(duster) < 0.025). Taken together, these results suggest that amygdala connectivity may be a potentially effective neuroimaging biomarker for comorbid depressive symptoms in chronic TBI.en_US
dc.description.sponsorship"This work has been supported by Department of Defense CDMRP grants W81XWH-11-2-0194 to DCK and W81XWH-11-2-0195 to SBC and a grant from the Meadows Foundation to DCK and SBC."en_US
dc.description.uriSupplementary information available at: http://journal.frontiersin.org/article/10.3389/fneur.2015.00231en_US
dc.identifier.bibliographicCitationHan, Kihwan, Sandra B. Chapman, and Daniel C. Krawczyk. 2015. "Altered amygdala connectivity in individuals with chronic traumatic brain injury and comorbid depressive symptoms." Frontiers In Neurology 6 (231), doi: 10.3389/fneur.2015.00231.en_US
dc.identifier.issn1664-2295en_US
dc.identifier.issue231en_US
dc.identifier.urihttp://hdl.handle.net/10735.1/4806
dc.identifier.volume6en_US
dc.language.isoenen_US
dc.publisherFrontiers Media S.A.en_US
dc.relation.urihttp://dx.doi.org/10.3389/fneur.2015.00231
dc.rightsCC BY 4.0 (Attribution)en_US
dc.rights©2015 The Authors.en_US
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en_US
dc.source.journalFrontiers in Neurologyen_US
dc.subjectBrain Injuriesen_US
dc.subjectDepressionen_US
dc.subjectMagnetic Resonance Imagingen_US
dc.subjectAmygdalaen_US
dc.subjectBattelle Developmental Inventoryen_US
dc.subjectBeck Depression Inventory-IIen_US
dc.subjectIntrinsic Functional Connectivityen_US
dc.subjectTreatment-Resistant Depressive Disorderen_US
dc.subjectPost-Traumatic Stress Disordersen_US
dc.subjectGlobal Signal Regressionen_US
dc.subjectPrefrontal Cortexen_US
dc.subjectSelf-consciousness (Awareness)en_US
dc.subjectCerebral Cortexen_US
dc.titleAltered Amygdala Connectivity in Individuals with Chronic Traumatic Brain Injury and Comorbid Depressive Symptomsen_US
dc.typeTexten_US
dc.type.genrearticleen_US

Files

Original bundle

Now showing 1 - 1 of 1
Thumbnail Image
Name:
CBH-3681-273739.60.pdf
Size:
4.38 MB
Format:
Adobe Portable Document Format
Description:
Article
Download

Collections

CBH Research
Chapman, Sandra Bond
Krawcewicz, Wieslaw