Effects of Repetitive Transcranial Magnetic Stimulation on the Connectivity of the Resting-State Triple Network in Cannabis Users

dc.contributor.advisorFilbey, Francesca M.
dc.creatorNoh, Eunsol
dc.date.accessioned2022-03-30T19:59:26Z
dc.date.available2022-03-30T19:59:26Z
dc.date.created2021-08
dc.date.issued2021-06-04
dc.date.submittedAugust 2021
dc.date.updated2022-03-30T19:59:27Z
dc.description.abstractA large number of studies have reported the association between pathological neural diseases (e.g., addicted disorders) and abnormal interactions in a large-scale brain network which is called the triple network. Cannabis users have shown dysfunctional interactions in the triple network during resting state (RS), which has been related to problematic symptoms of cannabis use. Among diverse tools, non-invasive repetitive transcranial magnetic stimulation (rTMS) has been introduced as an effective tool to moderate aberrant activity in the triple network. The posterior cingulate cortex (PCC) and precuneus are important hubs in the default mode network (DMN) and have cannabinoid receptors targeted by delta 9 tetrahydrocannabinol (THC) which is the main component of cannabis. This led us to test whether neuromodulation of these regions may moderate dysfunctional interactions between the areas of the triple network at rest. To that end, we collected electroencephalographic (EEG) recordings during RS after 10 Hz (high frequency, HF) and 1 Hz rTMS (low frequency, LF) in 12 cannabis users and 11 non-cannabis users. Using the exact Low-Resolution Electromagnetic Tomography (eLORETA) software, we examined connectivity strength in the triple network with resting-state EEG recordings. The results showed that HF rTMS to the PCC and precuneus has increased the delta connectivity following the LF rTMS between DMN and central executive network (CEN) in cannabis users, specifically between the PCC and left dorsolateral prefrontal cortex (dlPFC). In contrast, no effects of HF rTMS were observed in non-cannabis users. To sum up, our results present that HF rTMS to the PCC and precuneus can effectively modulate a partial connectivity (DMN-CEN) of large-scale network in cannabis users.
dc.format.mimetypeapplication/pdf
dc.identifier.urihttps://hdl.handle.net/10735.1/9380
dc.language.isoen
dc.subjectMagnetic brain stimulation
dc.subjectCannabis
dc.subjectMarijuana abuse
dc.subjectElectroencephalography
dc.subjectNeural networks (Neurobiology)
dc.titleEffects of Repetitive Transcranial Magnetic Stimulation on the Connectivity of the Resting-State Triple Network in Cannabis Users
dc.typeThesis
dc.type.materialtext
thesis.degree.departmentBiomedical Engineering
thesis.degree.grantorThe University of Texas at Dallas
thesis.degree.levelMasters
thesis.degree.nameMS

Files

Original bundle

Now showing 1 - 4 of 4
Loading...
Thumbnail Image
Name:
NOH-THESIS-2021.pdf
Size:
1.37 MB
Format:
Adobe Portable Document Format
No Thumbnail Available
Name:
EUNSOLNOH - dataset3 - MergedTMS.sav
Size:
432.24 KB
Format:
Unknown data format
No Thumbnail Available
Name:
EUNSOLNOH - dataset2 - Correlates of beahvior with baseline.sav
Size:
1.31 KB
Format:
Unknown data format
No Thumbnail Available
Name:
EUNSOLNOH - dataset - Main.sav
Size:
13.12 KB
Format:
Unknown data format

License bundle

Now showing 1 - 2 of 2
No Thumbnail Available
Name:
PROQUEST_LICENSE.txt
Size:
5.84 KB
Format:
Plain Text
Description:
No Thumbnail Available
Name:
LICENSE.txt
Size:
1.84 KB
Format:
Plain Text
Description: