Accelerating Chemical Exchange Saturation Transfer MRI with Parallel Blind Compressed Sensing

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dc.contributor.authorShe, H.
dc.contributor.authorGreer, Joshua S.
dc.contributor.authorZhang, S.
dc.contributor.authorLi, B.
dc.contributor.authorKeupp, J.
dc.contributor.authorMadhuranthakam, A. J.
dc.contributor.authorDimitrov, I. E.
dc.contributor.authorLenkinski, R. E.
dc.contributor.authorVinogradov, E.
dc.contributor.utdAuthorGreer, Joshua S.
dc.date.accessioned2019-07-12T19:13:28Z
dc.date.available2019-07-12T19:13:28Z
dc.date.created2018-08-26
dc.descriptionFull text access from Treasures at UT Dallas is restricted to current UTD affiliates (use the provided link to the article). Non UTD affiliates will find the web address for this item by clicking the Show full item record link and copying the "relation.uri" metadata.
dc.description.abstractPurpose: Chemical exchange saturation transfer is a novel and promising MRI contrast method, but it can be time-consuming. Common parallel imaging methods, like SENSE, can lead to reduced quality of CEST. Here, parallel blind compressed sensing (PBCS), combining blind compressed sensing (BCS) and parallel imaging, is evaluated for the acceleration of CEST in brain and breast. Methods: The CEST data were collected in phantoms, brain (N = 3), and breast (N = 2). Retrospective Cartesian undersampling was implemented and the reconstruction results of PBCS-CEST were compared with BCS-CEST and k-t sparse-SENSE CEST. The normalized RMSE and the high-frequency error norm were used for quantitative comparison. Results: In phantom and in vivo brain experiments, the acceleration factor of R = 10 (24 k-space lines) was achieved and in breast R = 5 (30 k-space lines), without compromising the quality of the PBCS-reconstructed magnetization transfer rate asymmetry maps and Z-spectra. Parallel BCS provides better reconstruction quality when compared with BCS, k-t sparse-SENSE, and SENSE methods using the same number of samples. Parallel BCS overperforms BCS, indicating that the inclusion of coil sensitivity improves the reconstruction of the CEST data. Conclusion: The PBCS method accelerates CEST without compromising its quality. Compressed sensing in combination with parallel imaging can provide a valuable alternative to parallel imaging alone for accelerating CEST experiments.
dc.description.departmentErik Jonsson School of Engineering and Computer Science
dc.description.sponsorshipNIH. Grant Number: R21 EB020245. CPRIT. Grant Number: RP180031
dc.identifier.bibliographicCitationShe, H., J. S. Greer, S. Zhang, B. Li, et al. 2018. "Accelerating chemical exchange saturation transfer MRI with parallel blind compressed sensing." Magnetic Resonance In Medicine 81(1): 504-513, doi:10.1002/mrm.27400
dc.identifier.issn0740-3194
dc.identifier.issue1
dc.identifier.urihttps://hdl.handle.net/10735.1/6688
dc.identifier.volume81
dc.language.isoen
dc.publisherJohn Wiley and Sons Inc.
dc.relation.urihttp://dx.doi.org/10.1002/mrm.27400
dc.rights©2018 International Society for Magnetic Resonance in Medicine
dc.source.journalMagnetic Resonance In Medicine
dc.subjectMagnetic Resonance Imaging
dc.subjectContrast media (Diagnostic imaging)
dc.subjectNeuroimaging
dc.titleAccelerating Chemical Exchange Saturation Transfer MRI with Parallel Blind Compressed Sensing
dc.title.alternativeMagnetic Resonance In Medicine
dc.type.genrearticle

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