Sensorimotor Network Segregation Declines with Age and is Linked to GABA and to Sensorimotor Performance

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dc.contributor.VIAF74141364 (Park, DC)
dc.contributor.authorCassady, Kaitlin
dc.contributor.authorGagnon, Holly
dc.contributor.authorLalwani, Poortata
dc.contributor.authorSimmonite, Molly
dc.contributor.authorFoerster, Bradley
dc.contributor.authorPark, Denise C.
dc.contributor.authorPeltier, Scott J.
dc.contributor.authorPetrou, Myria
dc.contributor.authorTaylor, Stephan F.
dc.contributor.authorWeissman, Daniel H.
dc.contributor.authorSeidler, Rachael D.
dc.contributor.authorPolk, Thad A.
dc.contributor.utdAuthorPark, Denise C.
dc.date.accessioned2020-09-21T21:51:04Z
dc.date.available2020-09-21T21:51:04Z
dc.date.issued2018-11-09
dc.descriptionDue to copyright restrictions and/or publisher's policy full text access from Treasures at UT Dallas is limited to current UTD affiliates (use the provided Link to Article).
dc.descriptionSupplementary material is available on publisher's website. Use the DOI link below.
dc.description.abstractAging is typically associated with declines in sensorimotor performance. Previous studies have linked some age-related behavioral declines to reductions in network segregation. For example, compared to young adults, older adults typically exhibit weaker functional connectivity within the same functional network but stronger functional connectivity between different networks. Based on previous animal studies, we hypothesized that such reductions of network segregation are linked to age-related reductions in the brain's major inhibitory transmitter, gamma aminobutyric acid (GABA). To investigate this hypothesis, we conducted graph theoretical analyses of resting state functional MRI data to measure sensorimotor network segregation in both young and old adults. We also used magnetic resonance spectroscopy to measure GABA levels in the sensorimotor cortex and collected a battery of sensorimotor behavioral measures. We report four main findings. First, relative to young adults, old adults exhibit both less segregated sensorimotor brain networks and reduced sensorimotor GABA levels. Second, less segregated networks are associated with lower GABA levels. Third, less segregated networks and lower GABA levels are associated with worse sensorimotor performance. Fourth, network segregation mediates the relationship between GABA and performance. These findings link age-related differences in network segregation to age-related differences in GABA levels and sensorimotor performance. More broadly, they suggest a neurochemical substrate of age-related dedifferentiation at the level of large-scale brain networks.
dc.description.departmentSchool of Behavioral and Brain Sciences
dc.description.departmentCenter for Vital Longevity
dc.description.sponsorshipNational Institutes of Health (R01AG050523)
dc.identifier.bibliographicCitationCassady, Kaitlin, Holly Gagnon, Poortata Lalwani, Molly Simmonite, et al. 2019. "Sensorimotor network segregation declines with age and is linked to GABA and to sensorimotor performance." Neuroimage 186: 234-244, doi: 10.1016/j.neuroimage.2018.11.008
dc.identifier.issn1053-8119
dc.identifier.urihttps://dx.doi.org/10.1016/j.neuroimage.2018.11.008
dc.identifier.urihttps://hdl.handle.net/10735.1/8912
dc.identifier.volume186
dc.language.isoen
dc.publisherAcademic Press Inc Elsevier Science
dc.rights©2018 Elsevier
dc.source.journalNeuroimage
dc.subjectAging
dc.subjectSensorimotor integration
dc.subjectMediation (Statistics)
dc.subjectOlder people
dc.subjectBrain
dc.subjectCerebral cortex
dc.subjectSpectrum analysis
dc.subjectNeurosciences
dc.subjectNeurology
dc.subjectRadiology
dc.subjectNuclear medicine
dc.subjectDiagnostic imaging
dc.subject.meshgamma-Aminobutyric Acid
dc.titleSensorimotor Network Segregation Declines with Age and is Linked to GABA and to Sensorimotor Performance
dc.type.genrearticle

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