Differential Aging Trajectories of Modulation of Activation to Cognitive Challenge in APOEε4 Groups: Reduced Modulation Predicts Poorer Cognitive Performance

dc.contributor.ORCID0000-0001-5373-9026 (Kennedy, KM)en_US
dc.contributor.authorFoster, Chris M.en_US
dc.contributor.authorKennedy, Kristen M.en_US
dc.contributor.authorRodrigue, Karen M.en_US
dc.contributor.utdAuthorFoster, Chris M.en_US
dc.contributor.utdAuthorKennedy, Kristen M.en_US
dc.contributor.utdAuthorRodrigue, Karen M.en_US
dc.date.accessioned2018-08-20T16:35:49Z
dc.date.available2018-08-20T16:35:49Z
dc.date.created2017-07
dc.description.abstractThe present study was designed to investigate the effect of a genetic risk factor for Alzheimer's disease (AD), ApolipoproteinE ε4 (APOEε4), on the ability of the brain to modulate activation in response to cognitive challenge in a lifespan sample of healthy human adults. A community-based sample of 181 cognitively intact, healthy adults were recruited from the Dallas-Fort Worth metroplex. Thirty-oneAPOEε4+ individuals (48% women), derived from the parent sample, were matched based on sex, age, and years of education to 31 individuals who were APOEε4-negative (APOEε4-). Ages ranged from 20 to 86 years of age. Blood oxygen level-dependent functional magnetic resonance imaging was collected during the performance of a visuospatial distance judgment task with three parametric levels of difficulty. Multiple regression was used in a whole-brain analysis with age, APOE group, and their interaction predicting functional brain modulation in response to difficulty. Results revealed an interaction between age and APOE in a large cluster localized primarily to the bilateral precuneus. APOEε4- individuals exhibited age-invariant modulation in response to task difficulty, whereas APOEε4- individuals showed age-related reduction of modulation in response to increasing task difficulty compared with ε4- individuals. Decreased modulation in response to cognitive challenge was associated with reduced task accuracy as well as poorer name-face associative memory performance. Findings suggest that APOEε4 is associated with a reduction in the ability of the brain to dynamically modulate in response to cognitive challenge. Coupled with a significant genetic risk factor for AD, changes in modulation may provide additional information toward identifying individuals potentially at risk for cognitive decline associated with preclinical AD.en_US
dc.description.departmentSchool of Behavioral and Brain Sciencesen_US
dc.description.sponsorshipThis research was supported in part by National Institute on Aging Grants AG-036848 and AG-036818;en_US
dc.identifier.bibliographicCitationFoster, Chris M., Kristen M. Kennedy, and Karen M. Rodrigue. 2017. "Differential Aging Trajectories of Modulation of Activation to Cognitive Challenge in APOEε4 Groups: Reduced Modulation Predicts Poorer Cognitive Performance." The Journal of Neuroscience: The Official Journal of the Society for Neuroscience 37(29), doi:10.1523/JNEUROSCI.3900-16.2017en_US
dc.identifier.issn0270-6474en_US
dc.identifier.issue29en_US
dc.identifier.urihttp://hdl.handle.net/10735.1/6005
dc.identifier.volume37en_US
dc.language.isoenen_US
dc.relation.urihttp://dx.doi.org/10.1523/JNEUROSCI.3900-16.2017en_US
dc.rightsCC BY 4.0 (Attribution)en_US
dc.rights©2017 The Authors.en_US
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en_US
dc.source.journalThe Journal of Neuroscience : The Official Journal of the Society for Neuroscienceen_US
dc.subjectAgingen_US
dc.subjectAllelesen_US
dc.subjectAlzheimer's diseaseen_US
dc.subjectApolipoprotein Een_US
dc.subjectCognitionen_US
dc.subjectMagnetic Resonance Imagingen_US
dc.subjectLongevityen_US
dc.subjectMemory—Age factorsen_US
dc.subjectOlder peopleen_US
dc.titleDifferential Aging Trajectories of Modulation of Activation to Cognitive Challenge in APOEε4 Groups: Reduced Modulation Predicts Poorer Cognitive Performanceen_US
dc.typeTexten_US
dc.type.genrearticleen_US

Files

Original bundle

Now showing 1 - 1 of 1
Loading...
Thumbnail Image
Name:
BBS-5915-7999.15.pdf
Size:
1.24 MB
Format:
Adobe Portable Document Format
Description:
Article