Regulation of Morphogenesis and Neural Differentiation of Human Mesenchymal Stem Cells Using Carbon Nanotube Sheets

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dc.contributor.ISNI0000 0003 5232 4253 (Baughman, RH)
dc.contributor.authorKim, Jeong Ahen_US
dc.contributor.authorJang, Eui Yunen_US
dc.contributor.authorKang, Tae Juneen_US
dc.contributor.authorYoon, Sungjunen_US
dc.contributor.authorOvalle-Robles, Raquelen_US
dc.contributor.authorRhee, Won Jongen_US
dc.contributor.authorKim, Taewooen_US
dc.contributor.authorBaughman, Ray H.en_US
dc.contributor.authorKim, Yong Hyupen_US
dc.contributor.authorPark, Tai Hyunen_US
dc.contributor.utdAuthor|Ovalle-Robles, Raquelen_US
dc.contributor.utdAuthorBaughman, Ray H.en_US
dc.date.accessioned2014-02-27T19:28:47Z
dc.date.available2014-02-27T19:28:47Z
dc.date.created2012-04-02en_US
dc.date.issued2012-04-02en_US
dc.descriptionIncludes Supplementary Information.en_US
dc.description.abstractIn order to successfully utilize stem cells for therapeutic applications in regenerative medicine, efficient differentiation into a specific cell lineage and guidance of axons in a desired direction is crucial. Here, we used aligned multi-walled carbon nanotube (MWCNT) sheets to differentiate human mesenchymal stem cells (hMSCs) into neural cells. Human MSCs present a preferential adhesion to aligned CNT sheets with longitudinal stretch parallel to the CNT orientation direction. Cell elongation was 2-fold higher than the control and most of the cells were aligned on CNT sheets within 51 from the CNT orientation direction. Furthermore, a significant, synergistic enhancement of neural differentiation was observed in hMSCs cultured on the CNT sheets. Axon outgrowth was also controlled using nanoscale patterning of CNTs. This CNT sheet provides a new cellular scaffold platform that can regulate morphogenesis and differentiation of stem cells, which could open up a new approach for tissue and stem cell regeneration.en_US
dc.identifier.bibliographicCitationKim, Jeong Ah, Eui Yun Jang, Tae June Kang, Sungjun Yoon, et al. 2012. "Regulation of morphogenesis and neural differentiation of human mesenchymal stem cells using carbon nanotube sheets." Integrative Biology 4(6): 587-594.en_US
dc.identifier.issn1757-9694en_US
dc.identifier.issue6en_US
dc.identifier.startpage587en_US
dc.identifier.urihttp://hdl.handle.net/10735.1/3103
dc.identifier.volume4en_US
dc.relation.urihttp://dx.doi.org/10.1039/c2ib20017a
dc.rights©2013 The Royal Society of Chemistry. This article may not be further made available or distributed.en_US
dc.sourceIntegrative Biology
dc.subjectNanofibersen_US
dc.subjectNanostructuresen_US
dc.subjectMyogenesisen_US
dc.titleRegulation of Morphogenesis and Neural Differentiation of Human Mesenchymal Stem Cells Using Carbon Nanotube Sheetsen_US
dc.typeTexten_US
dc.type.genreArticleen_US

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