Development of Softening Polymer-based Spinal Cord Stimulation Leads for Chronic Applications

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dc.contributor.advisorVoit, Walter E.
dc.contributor.advisorPancrazio, Joseph
dc.contributor.advisorFrensley, William R.
dc.contributor.committeeMemberCogan, Stuart
dc.contributor.committeeMemberWare, Taylor
dc.creatorGarcia Sandoval, Aldo
dc.date.accessioned2023-03-27T15:10:32Z
dc.date.available2023-03-27T15:10:32Z
dc.date.created2021-12
dc.date.issued2021-12-01T06:00:00.000Z
dc.date.submittedDecember 2021
dc.date.updated2023-03-27T15:10:34Z
dc.description.abstractSpinal cord stimulation (SCS) leads are a type of neural interface that can be implanted in the epidural space and deliver electrical pulses to change or block signals traveling to the brain. SCS leads are commonly used to alleviate chronic back pain resulting from failed back surgery syndrome and other injury and disease-related conditions. Recently, researchers have tried to develop treatments to restore movement in patients with a spinal cord injury. However, clinical cervical SCS has been limited by the size of the SCS leads, the small epidural space around the cervical spinal cord, and the large degree of movement of the neck. Furthermore, commercially available SCS leads are not compatible for their use in small animal models where most of the preclinical research is done. Therefore, in this dissertation work, we (1) have developed a thinfilm softening SCS lead that can be implanted in the cervical spinal cord of a rat model and evoke muscle responses after SCS. (2) We have also developed ester-free nondegradable softening polymer-based SCS leads, and (3) have shown their in vitro long-term electrochemical stability to assess their potential use in chronic studies.
dc.format.mimetypeapplication/pdf
dc.identifier.uri
dc.identifier.urihttps://hdl.handle.net/10735.1/9625
dc.language.isoen
dc.subjectEngineering, Biomedical
dc.titleDevelopment of Softening Polymer-based Spinal Cord Stimulation Leads for Chronic Applications
dc.typeThesis
dc.type.materialtext
thesis.degree.collegeSchool of Engineering and Computer Science
thesis.degree.departmentBiomedical Engineering
thesis.degree.grantorThe University of Texas at Dallas
thesis.degree.namePHD

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