Distinct and Predictive Histone Lysine Acetylation Patterns at Promoters, Enhancers, and Gene Bodies

Simple item page
dc.contributor.ISNI0000 0001 1707 1372 (Zhang, MQ)
dc.contributor.LCNA99086074‏ (Zhang, MQ)en_US
dc.contributor.authorRajagopal, Nishaen_US
dc.contributor.authorErnst, Jasonen_US
dc.contributor.authorRay, Pradiptaen_US
dc.contributor.authorWu, Jieen_US
dc.contributor.authorZhang, Michael Q.en_US
dc.contributor.authorKellis, Manolisen_US
dc.contributor.authorRen, Bingen_US
dc.contributor.utdAuthorZhang, Michael Q.en_US
dc.date.accessioned2015-01-30T22:52:04Z
dc.date.available2015-01-30T22:52:04Z
dc.date.created2014-11-01en_US
dc.date.issued2014-11-01en_US
dc.description.abstractIn eukaryotic cells, histone lysines are frequently acetylated. However, unlike modifications such as methylations, histone acetylation modifications are often considered redundant. As such, the functional roles of distinct histone acetylations are largely unexplored. We previously developed an algorithm RFECS to discover the most informative modifications associated with the classification or prediction of mammalian enhancers. Here, we used this tool to identify the modifications most predictive of promoters, enhancers, and gene bodies. Unexpectedly, we found that histone acetylation alone performs well in distinguishing these unique genomic regions. Further, we found the association of characteristic acetylation patterns with genic regions and association of chromatin state with splicing. Taken together, our work underscores the diverse functional roles of histone acetylation in gene regulation and provides several testable hypotheses to dissect these roles.en_US
dc.description.sponsorshipUS National Institutes of Health Roadmap Epigenomics Program (U01 ES017166-01), sponsored by the National Institute on Drug Abuse (NIDA) and the National Institute of Environmental Health Sciences (NIEHS).en_US
dc.identifier.bibliographicCitationRajagopal, Nisha, Jason Ernst, Pradipta Ray, Jie Wu, et al. 2014. "Distinct and Predictive Histone Lysine Acetylation Patterns at Promoters, Enhancers, and Gene Bodies." G3−Genes Genomes Genetics 4(11): 2051-2063.en_US
dc.identifier.issn2160-1836en_US
dc.identifier.issue11en_US
dc.identifier.urihttp://hdl.handle.net/10735.1/4299
dc.identifier.volume4en_US
dc.language.isoenen_US
dc.publisherGenetics Society Americaen_US
dc.relation.urihttp://dx.doi.org/10.1534/g3.114.0/13565
dc.rightsCC BY 3.0 (Attribution)en_US
dc.rights©2014 The Authorsen_US
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/en_US
dc.sourceG3—Genes Genomes Genetics
dc.subjectHistonesen_US
dc.subjectAcetylationen_US
dc.subjectChromatinen_US
dc.subjectGenesen_US
dc.titleDistinct and Predictive Histone Lysine Acetylation Patterns at Promoters, Enhancers, and Gene Bodiesen_US
dc.type.genreArticleen_US

Files

Original bundle

Now showing 1 - 1 of 1
Thumbnail Image
Name:
NSM-MQZhang-271679.72.pdf
Size:
3.12 MB
Format:
Adobe Portable Document Format
Description:
ARTICLE
Download

Collections

Zhang, Michael Q.
CSB Research