A Wearable Biochemical Sensor for Monitoring Alcohol Consumption Lifestyle Through Ethyl Glucuronide (EtG) Detection in Human Sweat

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dc.contributor.ISNI0000 0001 2765 4678 (Prasad, S)en_US
dc.contributor.ORCID0000-0002-2404-3801 (Prasad, S)en_US
dc.contributor.authorPanneer Selvam, Anjanen_US
dc.contributor.authorMuthukumar, Sriramen_US
dc.contributor.authorKamakoti, Vikramshankaren_US
dc.contributor.authorPrasad, Shalinien_US
dc.contributor.utdAuthorPanneer Selvam, Anjan
dc.contributor.utdAuthorKamakoti, Vikramshankar
dc.contributor.utdAuthorPrasad, Shalini
dc.date.accessioned2018-01-22T22:32:39Z
dc.date.available2018-01-22T22:32:39Z
dc.date.created2016-03-21en_US
dc.description.abstractWe demonstrate for the first time a wearable biochemical sensor for monitoring alcohol consumption through the detection and quantification of a metabolite of ethanol, ethyl glucuronide (EtG). We designed and fabricated two co-planar sensors with gold and zinc oxide as sensing electrodes. We also designed a LED based reporting for the presence of EtG in the human sweat samples. The sensor functions on affinity based immunoassay principles whereby monoclonal antibodies for EtG were immobilized on the electrodes using thiol based chemistry. Detection of EtG from human sweat was achieved through chemiresistive sensing mechanism. In this method, an AC voltage was applied across the two coplanar electrodes and the impedance across the sensor electrodes was measured and calibrated for physiologically relevant doses of EtG in human sweat. EtG detection over a dose concentration of 0.001-100  μg/L was demonstrated on both glass and polyimide substrates. Detection sensitivity was lower at 1 μg/L with gold electrodes as compared to ZnO, which had detection sensitivity of 0.001 μg/L. Based on the detection range the wearable sensor has the ability to detect alcohol consumption of up to 11 standard drinks in the US over a period of 4 to 9 hours.;en_US
dc.identifier.bibliographicCitationPanneer Selvam, Anjan, Sriram Muthukumar, Vikramshankar Kamakoti, and Shalini Prasad. 2016. "A wearable biochemical sensor for monitoring alcohol consumption lifestyle through Ethyl glucuronide (EtG) detection in human sweat." Scientific Reports 6(23111), doi:10.1038/srep23111en_US
dc.identifier.issn2045-2322en_US
dc.identifier.urihttp://hdl.handle.net/10735.1/5623
dc.identifier.volume6en_US
dc.publisherNature Publishing Groupen_US
dc.relation.urihttp://dx.doi.org/10.1038/srep23111en_US
dc.rightsCC BY 4.0 (Attribution)en_US
dc.rights©2016 The Authors. All Rights Reserved.en_US
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en_US
dc.source.journalScientific Reportsen_US
dc.subjectBiochemical markersen_US
dc.subjectPerspirationen_US
dc.subjectZinc oxideen_US
dc.subjectEthyl glucuronideen_US
dc.subjectPolyimidesen_US
dc.subjectSignal processing—Digital techniquesen_US
dc.subjectDrinking of alcoholic beveragesen_US
dc.subjectEthanolen_US
dc.titleA Wearable Biochemical Sensor for Monitoring Alcohol Consumption Lifestyle Through Ethyl Glucuronide (EtG) Detection in Human Sweaten_US
dc.type.genrearticleen_US

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