Evaluation of Mammalian and Bacterial Cell Activity on Titanium Surface Coated with Dicationic Imidazolium-Based Ionic Liquids

dc.contributor.ORCID0000-0002-7343-9271 (Palmer, KL)en_US
dc.contributor.authorGindri, Izabelle M.en_US
dc.contributor.authorPalmer, Kelli L.en_US
dc.contributor.authorSiddiqui, Danyal A.en_US
dc.contributor.authorAghyarian, Shanten_US
dc.contributor.authorFrizzo, Clarissa P.en_US
dc.contributor.authorMartins, Marcos A. P.en_US
dc.contributor.authorRodrigues, Danieli C.en_US
dc.contributor.utdAuthorGindri, Izabelle M.en_US
dc.contributor.utdAuthorPalmer, Kelli L.en_US
dc.contributor.utdAuthorSiddiqui, Danyal A.en_US
dc.contributor.utdAuthorAghyarian, Shanten_US
dc.contributor.utdAuthorRodrigues, Danieli C.en_US
dc.date.accessioned2018-06-01T16:32:26Z
dc.date.available2018-06-01T16:32:26Z
dc.date.created2016-04-04
dc.date.issued2016-04-04en_US
dc.descriptionIncludes supplementary material.en_US
dc.description.abstractThis work presents a new strategy to protect titanium surfaces against bacterial colonization and biofilm formation using dicationic imidazolium-based ionic liquid coatings. Ionic liquids (ILs) were designed as multi-functional coatings and their compatibility with human gingival fibroblasts (HGF-1) and preosteoblast (MC3T3-E1) cells was investigated. Results demonstrated that IL coatings were stable and present on titanium surfaces after 7 days of immersion and showed that using phenylalanine as the anionic moiety allowed for cell proliferation and differentiation on titanium surface while also providing strong antimicrobial and anti-biofilm activity against bacterial strains relevant to the oral environment (Streptococcus sp.). Strains such as Streptococcus mutans, S. sanguinis, S salivarius, S. gordonii and S. uberis are known to colonize the surface of dental implants in the early stages after implantation (early colonizers), compromising the success of these devices. The "race for the surface" between cells and bacteria was established by correlating results obtained from cell proliferation (epithelial and osteoblast) and differentiation (osteoblast) studies with that of antimicrobial activity against early bacterial colonizers.en_US
dc.description.sponsorshipUniverdal Proc/Proc. (475556/2012-7, and 474895/2013-0); Rio Grande do Sul Foundation for Research Support (FAPERGS)—Proc. 2262-2551/14-1 and 2290-2551/14-1en_US
dc.identifier.bibliographicCitationGindri, Izabelle M., Kelli L. Palmer, Danyal A. Siddiqui, Shant Aghyarian, et al. 2016. "Evaluation of mammalian and bacterial cell activity on titanium surface coated with dicationic imidazolium-based ionic liquids." RSC Advances 6(43), doi: 10.1039/c6ra01003ben_US
dc.identifier.issn2046-2069en_US
dc.identifier.issue43en_US
dc.identifier.urihttp://hdl.handle.net/10735.1/5818
dc.identifier.volume6en_US
dc.language.isoenen_US
dc.publisherRoyal Soc Chemistryen_US
dc.relation.urihttp://dx.doi.org/10.1039/c6ra01003b
dc.rights©2016 The Royal Society of Chemistry. This article may not be further made available or distributed.en_US
dc.sourceRSC Advances
dc.subjectX-Ray photoelectron-spectroscopyen_US
dc.subjectDental implantsen_US
dc.subjectOsseointegrationen_US
dc.subjectBiofilmsen_US
dc.subjectPeri-Implantitisen_US
dc.subjectAmino acidsen_US
dc.subjectChlorhexidineen_US
dc.titleEvaluation of Mammalian and Bacterial Cell Activity on Titanium Surface Coated with Dicationic Imidazolium-Based Ionic Liquidsen_US
dc.type.genrearticleen_US

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