Renal Clearable Luminescent Gold Nanoparticles for In-Vitro Bioimaging

Date

2017-05

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Abstract

Renal clearable fluorescent gold nanoparticles (AuNPs) have potential to become tumor imaging and drug delivery agents because of their minimized accumulation in the body. However, they cannot actively target tumor receptors at both in vitro and in vivo levels. Since transferrin, a proliferative protein, has been widely used for targeted delivery of nanoparticles, in this thesis, we investigated targeting of transferrin after being conjugated with renal clearable fluorescent gold nanoparticles at the in vitro cellular level. Our results show that transferrin lost its targeting functionality due to the conjugation renal clearable AuNPs while it still can retain targeting capabilities after being conjugated onto organic dyes. Our further studies use a well-known ligand, biotin, also lost its binding affinity to avidin. Renal clearable AuNPs effect on the functionality of active targeting ligands are highly complicated, which demands extensive efforts in the future studies.

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Keywords

Nanoparticles, Gold, Transferrin, Renal circulation

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©2017 The Author. Digital access to this material is made possible by the Eugene McDermott Library. Further transmission, reproduction or presentation (such as public display or performance) of protected items is prohibited except with permission of the author.

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