Renal Clearable Luminescent Gold Nanoparticles for In-Vitro Bioimaging

dc.contributor.advisorZheng, Jie
dc.creatorJacobe, Jessica L
dc.date.accessioned2018-05-31T14:36:05Z
dc.date.available2018-05-31T14:36:05Z
dc.date.created2017-05
dc.date.issued2017-05
dc.date.submittedMay 2017
dc.date.updated2018-05-31T14:36:05Z
dc.description.abstractRenal clearable fluorescent gold nanoparticles (AuNPs) have potential to become tumor imaging and drug delivery agents because of their minimized accumulation in the body. However, they cannot actively target tumor receptors at both in vitro and in vivo levels. Since transferrin, a proliferative protein, has been widely used for targeted delivery of nanoparticles, in this thesis, we investigated targeting of transferrin after being conjugated with renal clearable fluorescent gold nanoparticles at the in vitro cellular level. Our results show that transferrin lost its targeting functionality due to the conjugation renal clearable AuNPs while it still can retain targeting capabilities after being conjugated onto organic dyes. Our further studies use a well-known ligand, biotin, also lost its binding affinity to avidin. Renal clearable AuNPs effect on the functionality of active targeting ligands are highly complicated, which demands extensive efforts in the future studies.
dc.format.mimetypeapplication/pdf
dc.identifier.urihttp://hdl.handle.net/10735.1/5771
dc.language.isoen
dc.rights©2017 The Author. Digital access to this material is made possible by the Eugene McDermott Library. Further transmission, reproduction or presentation (such as public display or performance) of protected items is prohibited except with permission of the author.
dc.subjectNanoparticles
dc.subjectGold
dc.subjectTransferrin
dc.subjectRenal circulation
dc.titleRenal Clearable Luminescent Gold Nanoparticles for In-Vitro Bioimaging
dc.typeThesis
dc.type.materialtext
thesis.degree.departmentChemistry
thesis.degree.grantorThe University of Texas at Dallas
thesis.degree.levelMasters
thesis.degree.nameMS

Files

Original bundle

Now showing 1 - 1 of 1
Loading...
Thumbnail Image
Name:
ETD-5608-007-JACOBE-7888.87.pdf
Size:
1.36 MB
Format:
Adobe Portable Document Format
Description:

License bundle

Now showing 1 - 2 of 2
No Thumbnail Available
Name:
LICENSE.txt
Size:
1.84 KB
Format:
Plain Text
Description:
No Thumbnail Available
Name:
PROQUEST_LICENSE.txt
Size:
5.84 KB
Format:
Plain Text
Description: