Ultrasensitive and Rapid-Response Sensor for the Electrochemical Detection of Antibiotic Residues within Meat Samples

dc.contributor.ORCID0000-0002-2404-3801 (Prasad, S)
dc.contributor.authorStevenson, Hunter S.
dc.contributor.authorShetty, Shubrath S.
dc.contributor.authorThomas, Noel J.
dc.contributor.authorDhamu, Vidram N.
dc.contributor.authorBhide, Ashlesha
dc.contributor.authorPrasad, Shalini
dc.contributor.utdAuthorStevenson, Hunter S.
dc.contributor.utdAuthorShetty, Shubrath S.
dc.contributor.utdAuthorThomas, Noel J.
dc.contributor.utdAuthorDhamu, Vidram N.
dc.contributor.utdAuthorBhide, Ashlesha
dc.contributor.utdAuthorPrasad, Shalini
dc.date.accessioned2019-12-18T22:05:45Z
dc.date.available2019-12-18T22:05:45Z
dc.date.created2019
dc.description.abstractAntimicrobial use in livestock has emerged as a pressing global issue because of the rise of antimicrobial-resistant bacteria. Regulatory authorities across the globe have taken steps to discourage the misuse of these antibiotics by banning or limiting the use of medically important antibiotics in food animals. However, to ensure that food animals are not being administered antibiotics inappropriately, there is a need for a reliable, raid-response biosensor that can detect the presence of these antibiotic residuals in meat products. We have developed an affinity-based electrochemical biosensor for the label-free detection of ceftiofur residues in meat samples. The sensor uses a self-assembled immunoassay to target the ceftiofur biomarker by employing electrochemical impedance spectroscopy to probe the interfacial capacitive changes as ceftiofur binds to the sensor surface. We have demonstrated a platform that can detect ceftiofur within 15 min of introducing the sample at concentrations down to 0.01 ng/mL in 1× phosphate-buffered saline and 10 ng/mL in 220 mg ground turkey meat samples. © 2019 American Chemical Society.
dc.description.departmentSchool of Natural Sciences and Mathematics
dc.identifier.bibliographicCitationStevenson, H. S., S. S. Shetty, N. J. Thomas, V. N. Dhamu, et al. 2019. "Ultrasensitive and Rapid-Response Sensor for the Electrochemical Detection of Antibiotic Residues within Meat Samples." ACS Omega 4(4): 6324-6330, doi: 10.1021/acsomega.8b03534
dc.identifier.issn2470-1343
dc.identifier.issueImmunology
dc.identifier.urihttps://hdl.handle.net/10735.1/7134
dc.identifier.volume4
dc.language.isoen
dc.publisherAmerican Chemical Society
dc.relation.urihttps://dx.doi.org/10.1021/acsomega.8b03534
dc.rightsOpen Access through ACS AuthorChoice
dc.rights©2019 American Chemical Society
dc.rights.urihttps://pubs.acs.org/page/policy/authorchoice_termsofuse.html
dc.source.journalACS Omega
dc.subjectAnti-infective agents
dc.subjectDetectors
dc.subjectPeptides
dc.subjectProteins
dc.titleUltrasensitive and Rapid-Response Sensor for the Electrochemical Detection of Antibiotic Residues within Meat Samples
dc.type.genrearticle

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