Niclosamide Ethanolamine Improves Diabetes and Diabetic Kidney Disease in Mice

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dc.contributor.authorHan, Pengxun
dc.contributor.authorShao, Mumin
dc.contributor.authorGuo, Lan
dc.contributor.authorWang, Wenjing
dc.contributor.authorSong, Gaofeng
dc.contributor.authorYu, Xuewen
dc.contributor.authorZhang, Chunlei
dc.contributor.authorGe, Na
dc.contributor.authorYi, Tiegang
dc.contributor.authorLi, Shunmin
dc.contributor.authorDu, Heng
dc.contributor.authorSun, Huili
dc.contributor.utdAuthorGuo, Lan
dc.contributor.utdAuthorDu, Heng
dc.date.accessioned2019-05-31T21:02:57Z
dc.date.available2019-05-31T21:02:57Z
dc.date.created2018-04-15
dc.descriptionIncludes supplementary material
dc.description.abstractDiabetes and its renal complications are major medical challenges worldwide. There are no effective drugs currently available for treating diabetes and diabetic kidney disease (DKD), especially in type 1 diabetes (T1D). Evidence has suggested that niclosamide ethanolamine salt (NEN) could improve diabetic symptoms in mice of type 2 diabetes (T2D). However, its role in T1D and DKD has not been studied to date. Here we report that NEN could protect against diabetes in streptozotocin (STZ) induced T1D mice. It increased serum insulin levels, corrected the unbalanced ratio of alpha-cells to beta-cells, and induced islet morphologic changes under diabetic conditions. In addition, NEN could impede the progression of DKD in T1D. Specifically, it reduced urinary albumin levels, NAG, NGAL and TGF-beta 1 excretion, ameliorated renal hypertrophy, alleviated podocyte dysfunction, and suppressed the renal cortical activation of mTOR/4E-BP1 signaling pathway. Moreover, it is hepatoprotective and does not exhibit heart toxicity. Therefore, these findings open up a completely novel therapy for diabetes and DKD.
dc.description.departmentSchool of Natural Sciences and Mathematics
dc.identifier.bibliographicCitationHan, Pengxun, Mumin Shao, Lan Guo, Wenjing Wang, et al. 2018. "Niclosamide ethanolamine improves diabetes and diabetic kidney disease in mice." American Journal of Translational Research 10(4): 1071-1084.
dc.identifier.issn1943-8141
dc.identifier.issue4
dc.identifier.urihttps://hdl.handle.net/10735.1/6538
dc.identifier.volume10
dc.publishere-Century Publishing Corporation
dc.rightsCC BY-NC 4.0 (Attribution-NonCommercial)
dc.rights©2018 e-Century Publishing Corporation
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/
dc.source.journalAmerican Journal of Translational Research
dc.subjectDiabetes Mellitus
dc.subjectDiabetic Nephropathies
dc.subjectInsulin
dc.subjectRats
dc.titleNiclosamide Ethanolamine Improves Diabetes and Diabetic Kidney Disease in Mice
dc.type.genrearticle

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