Diagnosis and Treatment of Small Bowel Cancers Using Radioactive Gold Nanoparticles and Wireless Fluorescence Capsule Endoscopy

dc.contributor.authorAlizadeh, M.en_US
dc.contributor.authorQaradaghi, Vahiden_US
dc.contributor.utdAuthorQaradaghi, Vahid
dc.date.accessioned2016-09-23T20:36:12Z
dc.date.available2016-09-23T20:36:12Z
dc.date.created2016-03
dc.description.abstractBackground: Therapeutic and diagnosis properties of radioactive gold nanoparticle (198-AuNPs) cause them to be suitable for detection and treatment of tumors. Objective: Electrical and optical properties of PEG-198AuNPs were examined in this paper. Polyethylene Glycol (PEG)-198 AuNPs can be used for treatment and diagnosis of small intestine tumors. Methods: Wireless fluorescence capsule endoscopy will be able to detect emission lights of triggered Au by external light. First, the output electrical field was calculated by DDSCAT software. Secondly, tumor and distribution of PEG-198 gold nanoparticles were modeled using Monte Carlo simulation and finally dose delivered throughout a solid tumor when the PEG-198 gold nanoparticles linked to each cell was calculated. Results: Polyethylene Glycol functionalized gold nanoparticles (AuNPs) possess optimized sizes (30 nm core diameter and 70 nm hydrodynamic diameters) to target individual tumor cells. Surface distribution to receive doses of up to 50Gy was simulated. Activities and absorbed doses by the tumors with 0.25cm and 0.5cm radius were 187.9mCi and 300mCi and 72 and 118 Gy, respectively. Conclusion: Therapeutic and diagnosis properties of 198-AuNPs show that it can be used for treatment and detection of small bowel tumors in early stage of growing.en_US
dc.identifier.bibliographicCitationAlizadeh, M., and V. Qaradaghi. 2016. "Diagnosis and treatment of small bowel cancers using radioactive gold nanoparticles and wireless fluorescence capsule endoscopy." Journal of Biomedical Physics and Engineering 6(1): 13-20.en_US
dc.identifier.issn2251-7200en_US
dc.identifier.issue1en_US
dc.identifier.urihttp://hdl.handle.net/10735.1/5045
dc.identifier.volume6en_US
dc.language.isoenen_US
dc.publisherShiraz University of Medical Sciencesen_US
dc.relation.urihttp://dx.doi.org/10.1016/j.apradiso.2007.08.017
dc.rightsCC BY-NC 3.0 (Attribution-NonCommercial) Licenseen_US
dc.rights©2016 The Authorsen_US
dc.rights.urihttp://creativecommons.org/licenses/by-nc/3.0/en_US
dc.source.journalJournal of Biomedical Physics and Engineeringen_US
dc.subjectPolyethylene glycol--Biotechnologyen_US
dc.subjectNanoparticlesen_US
dc.subjectIntestine, Smallen_US
dc.subjectCapsule endoscopyen_US
dc.subjectIntestine, Small--Canceren_US
dc.titleDiagnosis and Treatment of Small Bowel Cancers Using Radioactive Gold Nanoparticles and Wireless Fluorescence Capsule Endoscopyen_US
dc.type.genrearticleen_US

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