17-β-Estradiol Induces Spreading Depression and Pain Behavior in Alert Female Rats

dc.contributor.authorSandweiss, Alexander J.en_US
dc.contributor.authorCottier, Karissa E.en_US
dc.contributor.authorMcIntosh, Mary I.en_US
dc.contributor.authorDussor, Gregoryen_US
dc.contributor.authorDavis, Thomas P.en_US
dc.contributor.authorVanderah, Todd W.en_US
dc.contributor.authorLargent-Milnes, Tally M.en_US
dc.contributor.utdAuthorDussor, Gregoryen_US
dc.date.accessioned2018-10-23T15:14:47Z
dc.date.available2018-10-23T15:14:47Z
dc.date.created2017-12-09
dc.description.abstractAims: Test the putative contribution of 17-β-estradiol in the development of spreading depression (SD) events and head pain in awake, non-restrained rats. Main Methods: Female, Sprague-Dawley rats were intact or underwent ovariectomy followed one week later by surgery to place electrodes onto the dura to detect epidural electroencephalographic activity (dEEG). dEEG activity was recorded two days later for 12 hours after systemic administration of 17-β-estradiol (180 μg/kg, i.p.). A separate set of rats were observed for changes in exploratory, ambulatory, fine, and rearing behaviors; periorbital allodynia was also assessed. Key Findings: A bolus of 17-β-estradiol significantly elevated serum estrogen levels, increased SD episodes over a 12-hour recording period and decreased rearing behaviors in ovariectomized rats. Pre-administration of ICI 182,780, an estrogen receptor antagonist, blocked 17-β-estradiol-evoked SD events and pain behaviors; similar results were observed when the antimigraine therapeutic sumatriptan was used. Significance: These data indicate that an estrogen receptor-mediated mechanism contributes to SD events in ovariectomized rats and pain behaviors in both ovariectomized -and intact-rats. This suggests that estrogen plays a different role in each phenomenon of migraine where intense fluctuations in concentration may influence SD susceptibility. This is the first study to relate estrogen peaks to SD development and pain behaviors in awake, freely moving female rats, establishing a framework for future preclinical migraine studies.en_US
dc.description.departmentSchool of Behavioral and Brain Sciencesen_US
dc.description.sponsorshipNIH Grants 5 RO1 DA 11271-18 and 5 RO1 NS 42652-14.en_US
dc.identifier.bibliographicCitationSandweiss, Alexander J., Karissa E. Cottier, Mary I. McIntosh, Gregory Dussor, et al. 2017. "17-β-Estradiol induces spreading depression and pain behavior in alert female rats." Oncotarget 8(69), 114109-114122, doi:10.18632/oncotarget.23141en_US
dc.identifier.issn1949-2553en_US
dc.identifier.issue69en_US
dc.identifier.urihttp://hdl.handle.net/10735.1/6246
dc.identifier.volume8en_US
dc.language.isoenen_US
dc.publisherImpact Journals LLCen_US
dc.relation.urihttp://dx.doi.org/10.18632/oncotarget.23141en_US
dc.rightsCC BY 3.0 (Attribution)en_US
dc.rights©2017 The Authorsen_US
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/en_US
dc.source.journalOncotargeten_US
dc.subjectQuality of lifeen_US
dc.subjectTrigeminal Nucleus, Spinalen_US
dc.subjectCerebral cortexen_US
dc.subjectSex differencesen_US
dc.subjectSpreading cortical depressionen_US
dc.subjectElectroencephalographyen_US
dc.subjectEstradiolen_US
dc.subjectHormone therapyen_US
dc.subjectMigraine auraen_US
dc.subjectOvariectomyen_US
dc.subjectCortical Spreading Depressionen_US
dc.title17-β-Estradiol Induces Spreading Depression and Pain Behavior in Alert Female Ratsen_US
dc.typeTexten_US
dc.type.genrearticleen_US

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