Impaired Spatial Memory and Enhanced Habit Memory in a Rat Model of Post-Traumatic Stress Disorder

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dc.contributor.authorGoodman, Jariden_US
dc.contributor.authorMcIntyre, Christa K.en_US
dc.contributor.utdAuthorGoodman, Jariden_US
dc.contributor.utdAuthorMcIntyre, Christa K.en_US
dc.date.accessioned2018-08-20T17:58:01Z
dc.date.available2018-08-20T17:58:01Z
dc.date.created2017-09-22
dc.description.abstractHigh levels of emotional arousal can impair spatial memory mediated by the hippocampus, and enhance stimulus-response (S-R) habit memory mediated by the dorsolateral striatum (DLS). The present study was conducted to determine whether these memory systems may be similarly affected in an animal model of post-traumatic stress disorder (PTSD). Sprague-Dawley rats were subjected to a "single-prolonged stress" (SPS) procedure and 1 week later received training in one of two distinct versions of the plus-maze: a hippocampus-dependent place learning task or a DLS-dependent response learning task. Results indicated that, relative to non-stressed control rats, SPS rats displayed slower acquisition in the place learning task and faster acquisition in the response learning task. In addition, extinction of place learning and response learning was impaired in rats exposed to SPS, relative to non-stressed controls. The influence of SPS on hippocampal spatial memory and DLS habit memory observed in the present study may be relevant to understanding some common features of PTSD, including hippocampal memory deficits, habit-like avoidance responses to trauma-related stimuli, and greater likelihood of developing drug addiction and alcoholism.en_US
dc.description.sponsorshipNational Institute of Mental Health MH105014 and MH104384.en_US
dc.identifier.bibliographicCitationGoodman, Jarid, and Christa K. McIntyre. 2017. "Impaired spatial memory and enhanced habit memory in a rat model of post-traumatic stress disorder." Frontiers in Pharmacology 8, doi:10.3389/fphar.2017.00663en_US
dc.identifier.issn1663-9812en_US
dc.identifier.urihttp://hdl.handle.net/10735.1/6009
dc.identifier.volume8en_US
dc.language.isoenen_US
dc.publisherFrontiers Media SAen_US
dc.relation.urihttp://dx.doi.org/10.3389/fphar.2017.00663en_US
dc.rightsCC BY 4.0 (Attribution)en_US
dc.rights©2017 The Authorsen_US
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en_US
dc.source.journalFrontiers in Pharmacologyen_US
dc.subjectAnxietyen_US
dc.subjectSubstance useen_US
dc.subjectHippocampusen_US
dc.subjectReceptors, N-Methyl-D-Aspartateen_US
dc.subjectNoradrenergicen_US
dc.subjectActivityen_US
dc.subjectPharmacology & pharmacyen_US
dc.subjectExtinction, Psychologicalen_US
dc.subjectMemoryen_US
dc.subjectStress Disorders, Post-Traumaticen_US
dc.titleImpaired Spatial Memory and Enhanced Habit Memory in a Rat Model of Post-Traumatic Stress Disorderen_US
dc.typeTexten_US
dc.type.genrearticleen_US

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