Gamma Oscillations During Episodic Memory Processing Provide Evidence for Functional Specialization in the Longitudinal Axis of the Human Hippocampus

dc.contributor.authorLin, Jui-Jui
dc.contributor.authorUmbach, Gray
dc.contributor.authorRugg, Michael D.
dc.contributor.authorLega, Bradley
dc.contributor.utdAuthorRugg, Michael D.
dc.descriptionDue to copyright restrictions and/or publisher's policy full text access from Treasures at UT Dallas is limited to current UTD affiliates (use the provided Link to Article).
dc.description.abstractThe question of whether the anterior and posterior hippocampus serve different or complementary functional roles during episodic memory processing has been motivated by noteworthy findings in rodent experiments and from noninvasive studies in humans. Researchers have synthesized these data to postulate several models of functional specialization, However, the issue has not been explored in detail using direct brain recordings. We recently published evidence that theta power increases during episodic memory encoding occur in the posterior hippocampus in humans. In our current investigation we analyzed an expanded data set of 32 epilepsy patients undergoing stereo EEG seizure mapping surgery with electrodes precisely targeted to the anterior and posterior hippocampus simultaneously who performed an episodic memory task. Using a repeated measures design, we looked for an interaction between encoding versus retrieval differences in gamma oscillatory power and anterior versus posterior hippocampal location. Our findings are consistent with a recently articulated model (the HERNET model) favoring posterior hippocampal activation during retrieval related processing. We also tested for encoding versus retrieval differences in the preferred gamma frequency band (high versus low gamma oscillations) motivated by published rodent data.
dc.description.departmentSchool of Behavioral and Brain Sciences
dc.description.departmentCenter for Vital Longevity
dc.description.sponsorshipDefense Advanced Research Projects Agency, Grant/Award Number: N66001‐14‐2‐4032; National Institute of Neurological Disorders and Stroke, Grant/Award Number: NS095094‐01A1
dc.identifier.bibliographicCitationLin, Jui-Jui, Gray Umbach, Michael D. Rugg, and Bradley Lega. 2019. "Gamma oscillations during episodic memory processing provide evidence for functional specialization in the longitudinal axis of the human hippocampus." Hippocampus 29(2): 68-72, doi: 10.1002/hipo.23016
dc.rights©2018 Wiley Periodicals, Inc.
dc.subjectEpisodic memory
dc.subjectHippocampus (Brain)
dc.subjectTemporal lobes (Medial)
dc.titleGamma Oscillations During Episodic Memory Processing Provide Evidence for Functional Specialization in the Longitudinal Axis of the Human Hippocampus


Original bundle

Now showing 1 - 1 of 1
Thumbnail Image
184.63 KB
Adobe Portable Document Format
Link to Article