Evaluation of Current Strategies for Surveillance and Management of Donor-Specific Antibodies: Single-Center Study

dc.contributor.authorSullivan, D.
dc.contributor.authorAhn, C.
dc.contributor.authorGao, A.
dc.contributor.authorLacelle, C.
dc.contributor.authorTorres, F.
dc.contributor.authorBollineni, S.
dc.contributor.authorBanga, A.
dc.contributor.authorMullins, J.
dc.contributor.authorMohanka, M.
dc.contributor.authorRing, S.
dc.contributor.authorWait, M.
dc.contributor.authorPeltz, M.
dc.contributor.authorDuddupudi, Pavan
dc.contributor.authorSurapaneni, D.
dc.contributor.authorKaza, V.
dc.contributor.utdAuthorDuddupudi, Pavan
dc.date.accessioned2019-07-12T20:50:52Z
dc.date.available2019-07-12T20:50:52Z
dc.date.created2018-05-17
dc.descriptionFull text access from Treasures at UT Dallas is restricted to current UTD affiliates (use the provided link to the article). Non UTD affiliates will find the web address for this item by clicking the Show full item record link and copying the "relation.uri" metadata.
dc.descriptionSupplementary material available at publisher's website
dc.description.abstractBackground: Although the presence of donor-specific antibodies (DSA) is known to impact lung allograft, limited data exist regarding DSA management. Methods: We did a retrospective study at our center evaluating DSA management in adult lung transplant recipients undergoing lung transplantation between January 1, 2010 and June 30, 2014. Study follow-up was completed through October 2017. All recipients were stratified into 2 groups based on the presence or absence of DSA. Those with DSA were evaluated for the impact of treatment of DSA. The primary outcomes were postlung transplant survival and freedom from bronchiolitis obliterans syndrome (BOS), subset of chronic lung allograft dysfunction (CLAD). Simon-Makuch method was used to estimate overall survival and BOS-free survival to account for DSA as time-dependent covariate. Survival differences between the groups were analyzed using time-dependent Cox proportional hazards model. Results: Sixty-four percent of 194 total subjects developed post-lung transplant DSA. Overall survival was different with worse survival in the DSA positive group that never cleared DSA (P =.002). BOS-free survival was lower, but did not reach significance in this group. Response to treatment was poor, with only 12 of 47 (25.5%) who received treatment demonstrating clearance of DSA. Conclusions: Donor-specific antibodies prevalence is high after lung transplantation. Clearance of DSA correlated with improved outcomes. Current therapeutic strategies against DSA are relatively ineffective. Multicenter collaborative studies will be required to evaluate current treatment strategies and other innovative modalities.
dc.description.departmentSchool of Natural Sciences and Mathematics
dc.identifier.bibliographicCitationSullivan, D., C. Ahn, A. Gao, C. Lacelle, et al. 2018. "Evaluation of current strategies for surveillance and management of donor-specific antibodies: Single-center study." Clinical Transplantation 32: art. e13285, doi:10.1111/ctr.13285
dc.identifier.issn0902-0063
dc.identifier.urihttps://hdl.handle.net/10735.1/6701
dc.identifier.volume32
dc.language.isoen
dc.publisher2018 John Wiley & Sons Ltd.
dc.relation.urihttp://dx.doi.org/10.1111/ctr.13285
dc.rights©2018 John Wiley & Sons
dc.source.journalClinical Transplantation
dc.subjectAllografts
dc.subjectAntibodies
dc.subjectLung Transplantation
dc.subjectGraft rejection
dc.subjectTransplantation of organs, tissues, etc
dc.titleEvaluation of Current Strategies for Surveillance and Management of Donor-Specific Antibodies: Single-Center Study
dc.title.alternativeClinical Transplantation
dc.type.genrearticle

Files

Original bundle

Now showing 1 - 1 of 1
Loading...
Thumbnail Image
Name:
NSM-2079-9784.41-LINK.pdf
Size:
164.3 KB
Format:
Adobe Portable Document Format
Description:
Link to Article