Preliminary Findings Demonstrating Latent Effects of Early Adolescent Marijuana Use Onset on Cortical Architecture

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dc.contributor.ISNI0000 0001 3618 6298 (Filbey, FM)en_US
dc.contributor.authorFilbey, Francesca M.en_US
dc.contributor.authorMcQueeny, Timen_US
dc.contributor.authorDeWitt, Samuel J.en_US
dc.contributor.authorMishra, Virendraen_US
dc.contributor.utdAuthorFilbey, Francesca M.
dc.contributor.utdAuthorMcQueeny, Tim
dc.contributor.utdAuthorDeWitt, Samuel J.
dc.date.accessioned2016-07-21T19:42:45Z
dc.date.available2016-07-21T19:42:45Z
dc.date.created2015-10-09
dc.description.abstractBackground: As the most commonly used illicit substance during early adolescence, long-term or latent effects of early adolescent marijuana use across adolescent developmental processes remain to be determined. Methods: We examined cortical thickness, gray/white matter border contrast (GWR) and local gyrification index (LGI) in 42 marijuana (MJ) users. Voxelwise regressions assessed early-onset (age = 16 years-old) differences and relationships to continued use while controlling for current age and alcohol use. Results: Although groups did not differ by onset status, groups diverged in their correlations between cannabis use and cortical architecture. Among early-onset users, continued years of MJ use and current MJ consumption were associated with thicker cortex, increased GWR and decreased LGI. Late-onset users exhibited the opposite pattern. This divergence was observed in all three morphological measures in the anterior dorsolateral frontal cortex (p < .05, FWE-corrected). Conclusions: Divergent patterns between current MJ use and elements of cortical architecture were associated with early MJ use onset. Considering brain development in early adolescence, findings are consistent with disruptions in pruning. However, divergence with continued use for many years thereafter suggests altered trajectories of brain maturation during late adolescence and beyond.en_US
dc.description.sponsorshipThis research was funded by the National Institute on Drug Abuse (R01 DA030344, Filbey).en_US
dc.identifier.bibliographicCitationFilbey, Francesca M., Tim McQueeny, Samuel J. DeWitt, and Virendra Mishra. 2015. "Preliminary findings demonstrating latent effects of early adolescent marijuana use onset on cortical architecture." Developmental Cognitive Neuroscience 16, doi:10.1016/j.dcn.2015.10.001.en_US
dc.identifier.issn1878-9293en_US
dc.identifier.urihttp://hdl.handle.net/10735.1/4960
dc.identifier.volume16en_US
dc.language.isoenen_US
dc.publisherElsevier Sci Ltden_US
dc.relation.urihttp://dx.doi.org/10.1016/j.dcn.2015.10.001en_US
dc.rightsCC BY-NC-ND 4.0 (Attribution-NonCommercial-NoDerivatives)en_US
dc.rights©2015 The Authors.en_US
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/en_US
dc.source.journalDevelopmental Cognitive Neuroscienceen_US
dc.subjectAdolescenceen_US
dc.subjectCannabisen_US
dc.subjectMarijuana Abuseen_US
dc.subjectMalformations of Cortical Developmenten_US
dc.subjectGyrificationen_US
dc.subjectMorphologyen_US
dc.subjectFreesurfer (Computer file)en_US
dc.subjectCerebral Cortexen_US
dc.subjectAge of Onseten_US
dc.subjectWhite Matteren_US
dc.subjectCognitive Developmenten_US
dc.subjectYoung adultsen_US
dc.subjectBrainen_US
dc.titlePreliminary Findings Demonstrating Latent Effects of Early Adolescent Marijuana Use Onset on Cortical Architectureen_US
dc.typeTexten_US
dc.type.genrearticleen_US

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Filbey, Francesca M.