Some Prospective Alternatives for Treating Pain: The Endocannabinoid System and its Putative Receptors GPR18 and GPR55

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dc.contributor.authorGuerrero-Alba, Raquel
dc.contributor.authorBarragán-Iglesias, Paulino
dc.contributor.authorGonzalez-Hernandez, Abimael
dc.contributor.authorValdez-Morales, Eduardo E.
dc.contributor.authorGranados-Soto, Vinicio
dc.contributor.authorCondes-Lara, Miguel
dc.contributor.authorRodriguez, Martin G.
dc.contributor.authorMarichal-Cancino, Bruno A.
dc.contributor.utdAuthorBarragán-Iglesias, Paulino
dc.date.accessioned2020-08-04T21:53:57Z
dc.date.available2020-08-04T21:53:57Z
dc.date.issued2019-01-08
dc.description.abstractBackground: Marijuana extracts (cannabinoids) have been used for several millennia for pain treatment. Regarding the site of action, cannabinoids are highly promiscuous molecules, but only two cannabinoid receptors (CB₁ and CB₂) have been deeply studied and classified. Thus, therapeutic actions, side effects and pharmacological targets for cannabinoids have been explained based on the pharmacology of cannabinoid CB₁/CB₂ receptors. However, the accumulation of confusing and sometimes contradictory results suggests the existence of other cannabinoid receptors. Different orphan proteins (e.g., GPR18, GPR55, GPR119, etc.) have been proposed as putative cannabinoid receptors. According to their expression, GPR18 and GPR55 could be involved in sensory transmission and pain integration. Methods: This article reviews select relevant information about the potential role of GPR18 and GPR55 in the pathophysiology of pain. Results: This work summarized novel data supporting that, besides cannabinoid CB₁ and CB₂ receptors, GPR18 and GPR55 may be useful for pain treatment. Conclusion: There is evidence to support an antinociceptive role for GPR18 and GPR55.
dc.description.departmentSchool of Behavioral and Brain Sciences
dc.description.departmentCenter for Advanced Pain Studies
dc.identifier.bibliographicCitationGuerrero-Alba, Raquel, Paulino Barragán-Iglesias, Abimael Gonzalez-Hernandez, Eduardo E. Valdez-Morales, et al. 2019. "Some Prospective Alternatives for Treating Pain: The Endocannabinoid System and its Putative Receptors GPR18 and GPR55." Frontiers in Pharmacology 9: art. 1496, doi: 10.3389/fphar.2018.01496
dc.identifier.issn1663-9812
dc.identifier.urihttp://dx.doi.org/10.3389/fphar.2018.01496
dc.identifier.urihttps://hdl.handle.net/10735.1/8771
dc.identifier.volume9
dc.language.isoen
dc.publisherFrontiers Media SA
dc.rightsCC BY 4.0 (Attribution)
dc.rights©2019 The Authors
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.source.journalFrontiers in Pharmacology
dc.subjectAmides (Fatty acid)
dc.subjectProtein kinases
dc.subjectSensory neurons, Primary
dc.subjectSpinal-cord
dc.subject.meshGPR18 protein, rat
dc.subject.meshGPR18 protein, human
dc.subject.meshGPR55 protein, rat
dc.subject.meshGPR55 protein, human
dc.subject.meshEndocannabinoids
dc.subject.meshReceptors, Cannabinoid
dc.subject.meshNociceptive Pain
dc.subject.meshReceptor, Cannabinoid, CB2
dc.subject.meshGanglia, Spinal
dc.subject.meshPeripheral Nerve Injuries
dc.titleSome Prospective Alternatives for Treating Pain: The Endocannabinoid System and its Putative Receptors GPR18 and GPR55
dc.type.genrearticle

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