Optimization of Transcranial Direct Current Stimulation of Dorsolateral Prefrontal Cortex for Tinnitus: A Non-Linear Dose-Response Effect

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dc.contributor.ORCID0000-0002-9906-1836 (Vanneste, S)
dc.contributor.authorShekhawat, Giriraj Singh
dc.contributor.authorVanneste, Sven
dc.contributor.authorShekhawat, Giriraj Singh
dc.contributor.utdAuthorVanneste, Sven
dc.date.accessioned2019-09-27T15:18:19Z
dc.date.available2019-09-27T15:18:19Z
dc.date.created2018-05-29
dc.description.abstractNeuromodulation is defined as the process of augmenting neuroplasticity via invasive or non-invasive methods. Tinnitus is the perception of sound in the absence of its external source. The objective of this study was to optimize the parameters of transcranial direct current stimulation (tDCS) of dorsolateral prefrontal cortex (DLPFC) for tinnitus suppression. The following factors were optimized in the dose-response design (n = 111): current intensity (1.5 mA or 2 mA), stimulation duration (20 min or 30 min), and number of stimulation sessions (2, 4, 6, 8, or 10), with a 3-4 day washout period between each session. Participants underwent a minimum of 2 sessions in 1 week or maximum of 10 sessions in 5 weeks' time. Tinnitus loudness was measured in pre-post design using a 10-point numeric rating scale. There was a significant reduction in tinnitus loudness after tDCS of DLPFC. There was no significant difference between the intensity and duration of stimulation. As the number of sessions increased, there was a higher reduction in the tinnitus loudness; however, this effect plateaued after 6 sessions.
dc.description.departmentSchool of Behavioral and Brain Sciences
dc.description.departmentCallier Center for Communication Disorders
dc.description.departmentCenter for BrainHealth
dc.identifier.bibliographicCitationShekhawat, Giriraj Singh, and Sven Vanneste. 2018. "Optimization of Transcranial Direct Current Stimulation of Dorsolateral Prefrontal Cortex for Tinnitus: A Non-Linear Dose-Response Effect." Scientific Reports 8(1): art. 8311, doi: 10.1038/s41598-018-26665-1
dc.identifier.issn2045-2322
dc.identifier.issue1
dc.identifier.urihttps://hdl.handle.net/10735.1/6898
dc.identifier.volume8
dc.language.isoen
dc.publisherNature Publishing Group
dc.relation.urihttp://dx.doi.org/10.1038/s41598-018-26665-1
dc.rightsCC BY 4.0 (Attribution)
dc.rights©2018 The Authors
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.source.journalScientific Reports
dc.subjectMotor cortex
dc.subjectBrain stimulation
dc.subjectDouble-Blind Method
dc.subjectPerception
dc.subjectTranscranial Direct Current Stimulation
dc.subjectTinnitus
dc.titleOptimization of Transcranial Direct Current Stimulation of Dorsolateral Prefrontal Cortex for Tinnitus: A Non-Linear Dose-Response Effect
dc.type.genrearticle

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