Developing a Drug Delivery and Imaging System on a Virus-Like Particle Platform

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dc.contributor.advisorGassensmith, Jeremiah J.
dc.creatorChen, Zhuo
dc.date.accessioned2020-04-06T19:47:04Z
dc.date.available2020-04-06T19:47:04Z
dc.date.created2018-08
dc.date.issued2018-08
dc.date.submittedAugust 2018
dc.date.updated2020-04-06T19:49:13Z
dc.description.abstractNanoparticle based therapeutics have been proved to improve therapeutic efficacy and reduce the off-target toxicity. However, poor monodispersity and long term bioaccumulation toxicity have been the obstacles for the biomedical applications. Viruses-like particles (VLPs) have emerged as promising natural nanoparticles, which are monodisperse, non-infectious and biodegradable. Each VLP is usually composed of hundreds of identical subunits, leading to a highly ordered quaternary structure and repetitive particle surface. These unique characteristics allow VLP to be chemically functionalized precisely and periodically. The proteinaceous viral capsids are a robust platform, and solvent exposed amino acids such as lysine, cysteine and tyrosine can be orthogonally modified with variety of bioconjugation techniques. Bacteriophage Qβ is one of the well-studied VLPs, which is 28 nm in diameter and composed of 180 identical coat proteins. In my study, Qβ was used as a robust platform for conjugation-induced fluorescent labelling for the application of in vitro cell tracking and developing a photocaged carrier for stimuli-responsive drug release.
dc.format.mimetypeapplication/pdf
dc.identifier.urihttps://hdl.handle.net/10735.1/7833
dc.language.isoen
dc.rights©2018 Zhuo Chen. All Rights Reserved.
dc.subjectNanoparticles
dc.subjectDrug delivery systems
dc.subjectFluorescence
dc.subjectImaging systems
dc.subjectBioconjugates
dc.titleDeveloping a Drug Delivery and Imaging System on a Virus-Like Particle Platform
dc.typeDissertation
dc.type.materialtext
thesis.degree.departmentChemistry
thesis.degree.grantorThe University of Texas at Dallas
thesis.degree.levelDoctoral
thesis.degree.namePHD

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