Identifying Tinnitus-Related Genes based on a Side-Effect Network Analysis

dc.contributor.authorElgoyhen, A. B.en_US
dc.contributor.authorLangguth, B.en_US
dc.contributor.authorNowak, W.en_US
dc.contributor.authorSchecklmann, M.en_US
dc.contributor.authorDe Ridder, D.en_US
dc.contributor.authorVanneste, Svenen_US
dc.date.accessioned2014-07-11T19:25:07Z
dc.date.available2014-07-11T19:25:07Z
dc.date.created2014-01-29
dc.description.abstractTinnitus, phantom sound perception, is a worldwide highly prevalent disorder for which no clear underlying pathology has been established and for which no approved drug is on the market. Thus, there is an urgent need for new approaches to understand this condition. We used a network pharmacology side-effect analysis to search for genes that are involved in tinnitus generation. We analyzed a network of 1,313 drug-target pairs, based on 275 compounds that elicit tinnitus as side effect and their targets reported in databases, and used a quantitative score to identify emergent significant targets that were more common than expected at random. Cyclooxigenase 1 and 2 were significant, which validates our approach, since salicylate is a known tinnitus generator. More importantly, we predict previously unknown tinnitus-related targets. The present results have important implications toward understanding tinnitus pathophysiology and might pave the way toward the design of novel pharmacotherapies.en_US
dc.identifier.bibliographicCitationElgoyhen, A. B., B. Langguth, W. Nowak, M. Schecklmann, et al. 2014. "Identifying tinnitus-related genes based on a side-effect network analysis." CPT: Pharmacometrics & Systems Pharmacology 3(e97): 1-10.en_US
dc.identifier.issn2163-8306en_US
dc.identifier.issuee97en_US
dc.identifier.urihttp://hdl.handle.net/10735.1/3654
dc.identifier.volume3en_US
dc.publisherNature Publishing Groupen_US
dc.relation.urihttp://dx.doi.org/10.1038/psp.2013.75en_US
dc.rightsCC BY-NC-ND 3.0 (Attribution-NonCommercial-NoDerivatives)en_US
dc.rights©2014 ASCPT.en_US
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/en_US
dc.source.journalCPT: Pharmacometrics & Systems Pharmacologyen_US
dc.subjectHyperacusisen_US
dc.subjectTinnitusen_US
dc.subjectHearing disordersen_US
dc.subjectHearing impaireden_US
dc.titleIdentifying Tinnitus-Related Genes based on a Side-Effect Network Analysisen_US
dc.typeTexten_US
dc.type.genrearticleen_US

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