Flexible Nanoporous Tunable Electrical Double Layer Biosensors for Sweat Diagnostics

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dc.contributor.ISNI0000 0001 2765 4678 (Prasad, S)en_US
dc.contributor.authorMunje, Rujuta D.en_US
dc.contributor.authorMuthukumar, Sriramen_US
dc.contributor.authorSelvam, Anjan Panneeren_US
dc.contributor.authorPrasad, Shalinien_US
dc.contributor.utdAuthorMunje, Rujuta D.
dc.contributor.utdAuthorSelvam, Anjan Panneer
dc.contributor.utdAuthorPrasad, Shalini
dc.date.accessioned2016-07-07T15:38:07Z
dc.date.available2016-07-07T15:38:07Z
dc.date.created2015-09
dc.descriptionIncludes supplementary informationen_US
dc.description.abstractAn ultra-sensitive and highly specific electrical double layer (EDL) modulated biosensor, using nanoporous flexible substrates for wearable diagnostics is demonstrated with the detection of the stress biomarker cortisol in synthetic and human sweat. Zinc oxide thin film was used as active region in contact with the liquid i.e. synthetic and human sweat containing the biomolecules. Cortisol detection in sweat was accomplished by measuring and quantifying impedance changes due to modulation of the double layer capacitance within the electrical double layer through the application of a low orthogonally directed alternating current (AC) electric field. The EDL formed at the liquid-semiconductor interface was amplified in the presence of the nanoporous flexible substrate allowing for measuring the changes in the alternating current impedance signal due to the antibody-hormone interactions at diagnostically relevant concentrations. High sensitivity of detection of 1 pg/mL or 2.75 pmol cortisol in synthetic sweat and 1 ng/mL in human sweat is demonstrated with these novel biosensors. Specificity in synthetic sweat was demonstrated using a cytokine IL-1β. Cortisol detection in human sweat was demonstrated over a concentration range from 10–200 ng/mL.en_US
dc.identifier.bibliographicCitationMunje, Rujuta D., Sriram Muthukumar, Anjan Panneer Selvam, and Shalini Prasad. 2015. "Flexible nanoporous tunable electrical double layer biosensors for sweat diagnostics." Scientific Reports 5, doi: 10.1038/srep14586 (2015).en_US
dc.identifier.issn2045-2322en_US
dc.identifier.urihttp://hdl.handle.net/10735.1/4912
dc.identifier.volume5en_US
dc.relation.urihttp://dx.doi.org/10.1038/srep14586en_US
dc.rightsCC BY 4.0 (Attribution)en_US
dc.rights©2015 The Authorsen_US
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en_US
dc.source.journalScientific Reportsen_US
dc.subjectBiomedical engineeringen_US
dc.subjectPolyamidesen_US
dc.subjectHydrocortisoneen_US
dc.subjectPerspirationen_US
dc.subjectZinc oxideen_US
dc.titleFlexible Nanoporous Tunable Electrical Double Layer Biosensors for Sweat Diagnosticsen_US
dc.type.genrearticleen_US

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