A High-Fat Diet Causes Impairment in Hippocampal Memory and Sex-Dependent Alterations in Peripheral Metabolism

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dc.contributor.ORCID0000-0001-8878-0221 (Thompson, LT)en_US
dc.contributor.authorUnderwood, Erica L.en_US
dc.contributor.authorThompson, Lucien T.en_US
dc.date.accessioned2016-07-21T20:01:23Z
dc.date.available2016-07-21T20:01:23Z
dc.date.created2016-01-01
dc.description.abstractWhile high-fat diets are associated with rising incidence of obesity/type-2 diabetes and can induce metabolic and cognitive deficits, sex-dependent comparisons are rarely systematically made. Effects of exclusive consumption of a high-fat diet (HFD) on systemic metabolism and on behavioral measures of hippocampal-dependent memory were compared in young male and female LE rats. Littermates were fed from weaning either a HFD or a control diet (CD) for 12 wk prior to testing. Sex-different effects of the HFD were observed in classic metabolic signs associated with type-2 diabetes. Males fed the HFD became obese, and had elevated fasted blood glucose levels, elevated corticosterone, and impaired glucose-tolerance, while females on the HFD exhibited only elevated corticosterone. Regardless of peripheral metabolism alteration, rats of both sexes fed the HFD were equally impaired in a spatial object recognition memory task associated with impaired hippocampal function. While the metabolic changes reported here have been characterized previously in males, the set of diet-induced effects observed here in females are novel. Impaired memory can have significant cognitive consequences, over the short-term and over the lifespan. A significant need exists for comparative research into sex-dependent differences underlying obesity and metabolic syndromes relating systemic, cognitive, and neural plasticity mechanisms.en_US
dc.identifier.bibliographicCitationUnderwood, E. L., and L. T. Thompson. 2016. "A high-fat diet causes impairment in hippocampal memory and sex-dependent alterations in peripheral metabolism." Neural Plasticity 2016, doi:10.1155/2016/7385314.en_US
dc.identifier.issn2090-5904en_US
dc.identifier.urihttp://hdl.handle.net/10735.1/4963
dc.identifier.volume2016en_US
dc.language.isoenen_US
dc.publisherHindawi Publishing Corporationen_US
dc.relation.urihttp://dx.doi.org/10.1155/2016/7385314en_US
dc.rightsCC BY 4.0 (Attribution)en_US
dc.rights©2016 The Authorsen_US
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en_US
dc.source.journalNeural Plasticityen_US
dc.subjectBlood sugaren_US
dc.subjectDiet, High-Faten_US
dc.subjectMemory disordersen_US
dc.subjectRatsen_US
dc.subjectNeuroplasticityen_US
dc.subjectObesityen_US
dc.subjectNon-insulin-dependent diabetesen_US
dc.subjectSex factors in diseaseen_US
dc.titleA High-Fat Diet Causes Impairment in Hippocampal Memory and Sex-Dependent Alterations in Peripheral Metabolismen_US
dc.typeTexten_US
dc.type.genrearticleen_US

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