Cyclopamine Tartrate, An Inhibitor of Hedgehog Signaling, Strongly Interferes with Mitochondrial Function and Suppresses Aerobic Respiration in Lung Cancer Cells

dc.contributor.VIAF250674117 (Izen, JM)en_US
dc.contributor.authorAad, G.en_US
dc.contributor.authorAbbott, B.en_US
dc.contributor.authorAbdallah, J.en_US
dc.contributor.authorAbdinov, O.en_US
dc.contributor.authorAbeloos, B.en_US
dc.contributor.authorAben, R.en_US
dc.contributor.authorAbolins, M.en_US
dc.contributor.authorIzen, Joseph M.en_US
dc.contributor.authorLeyton, Michaelen_US
dc.contributor.authorMeirose, Bernharden_US
dc.contributor.authorNamasivayam, Harisankaren_US
dc.contributor.authorReeves, Kendallen_US
dc.contributor.authorATLAS Collaborationen_US
dc.contributor.utdAuthorIzen, Joseph M.en_US
dc.contributor.utdAuthorLeyton, Michaelen_US
dc.contributor.utdAuthorMeirose, Bernharden_US
dc.contributor.utdAuthorNamasivayam, Harisankaren_US
dc.contributor.utdAuthorReeves, Kendallen_US
dc.date.accessioned2018-05-15T19:51:27Z
dc.date.available2018-05-15T19:51:27Z
dc.date.created2017-04-13en_US
dc.date.issued2018-05-15
dc.description.abstractThe reconstruction and calibration algorithms used to calculate missing transverse momentum (E_T^{miss}) with the ATLAS detector exploit energy deposits in the calorimeter and tracks reconstructed in the inner detector as well as the muon spectrometer. Various strategies are used to suppress effects arising from additional proton–proton interactions, called pileup, concurrent with the hard-scatter processes. Tracking information is used to distinguish contributions from the pileup interactions using their vertex separation along the beam axis. The performance of the E_T^{miss} reconstruction algorithms, especially with respect to the amount of pileup, is evaluated using data collected in proton–proton collisions at a centre-of-mass energy of 8 TeV during 2012, and results are shown for a data sample corresponding to an integrated luminosity of 20.3 fb⁻¹. The simulation and modelling of E_T^{miss} in events containing a Z boson decaying to two charged leptons (electrons or muons) or a W boson decaying to a charged lepton and a neutrino are compared to data. The acceptance for different event topologies, with and without high transverse momentum neutrinos, is shown for a range of threshold criteria for E_T^{miss}, and estimates of the systematic uncertainties in the E_T^{miss} measurements are presented.en_US
dc.description.departmentSchool of Natural Sciences and Mathematicsen_US
dc.identifier.bibliographicCitationAad, G., B. Abbott, J. Abdallah, O. Abdinov, et al. 2017. "Performance of algorithms that reconstruct missing transverse momentum in √s = 8 TeV proton–proton collisions in the ATLAS detector." European Physical Journal C 77(4), doi:10.1140/epjc/s10052-017-4780-2en_US
dc.identifier.issn1434-6044en_US
dc.identifier.issue4en_US
dc.identifier.urihttp://hdl.handle.net/10735.1/5743
dc.identifier.volume77en_US
dc.language.isoenen_US
dc.publisherSpringer New York LLCen_US
dc.relation.urihttp://dx.doi.org/10.1140/epjc/s10052-017-4780-2
dc.rightsCC BY 4.0 (Attribution)en_US
dc.rights©2017 CERN, for the ATLAS Collaborationen_US
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en_US
dc.sourceEuropean Physical Journal C
dc.subjectW bosonsen_US
dc.subjectZ bosonsen_US
dc.subjectProton-proton interactionsen_US
dc.subjectLeptons (Nuclear physics)en_US
dc.subjectTransverse momentumen_US
dc.titleCyclopamine Tartrate, An Inhibitor of Hedgehog Signaling, Strongly Interferes with Mitochondrial Function and Suppresses Aerobic Respiration in Lung Cancer Cellsen_US
dc.type.genrearticleen_US

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