Enhancing Executive Function and Neural Health in Bipolar Disorder Through Reasoning Training

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dc.contributor.ISNI0000 0003 5170 3614 (Chapman, SB)en_US
dc.contributor.authorVenza, Erin E.en_US
dc.contributor.authorChapman, Sandra Bonden_US
dc.contributor.authorAslan, Sinaen_US
dc.contributor.authorZientz, Jennifer E.en_US
dc.contributor.authorTyler, David L.en_US
dc.contributor.authorSpence, Jeffrey S.en_US
dc.contributor.utdAuthorVenza, Erin E.
dc.contributor.utdAuthorChapman, Sandra Bond
dc.contributor.utdAuthorAslan, Sina
dc.contributor.utdAuthorZientz, Jennifer E.
dc.contributor.utdAuthorTyler, David L.
dc.contributor.utdAuthorSpence, Jeffrey S.
dc.date.accessioned2017-12-01T22:26:17Z
dc.date.available2017-12-01T22:26:17Z
dc.date.created2016-11-01
dc.descriptionClinicalTrials.gov Identifier: NCT02843282en_US
dc.description.abstractCognitive deficits in executive function and memory among individuals with bipolar disorder (BD) are well-documented; however, only recently have efforts begun to address whether such cognitive deficits can be ameliorated through cognitive training. This pilot study examined the effects of a top–down, cognitive reasoning training program in adults with BD on both brain and cognitive measures. Twenty-seven participants (11 males, 16 females), aged 21–70 years old, completed the study. Participants completed neurocognitive testing and functional magnetic resonance imaging (fMRI) before and after training, consisting of 8 h (2 h/week) of training in small groups. The training delivered information processing strategies that were implemented and applicable to a variety of daily living contexts. Results indicated that participants showed significant gains in the primary outcome measure of complex abstraction, also referred to as gist reasoning, as well as in untrained domains of executive function and memory. We found a significant increase in resting cerebral blood flow (CBF) in left inferior frontal gyrus after cognitive training. We also found that resting CBF in the right frontal middle gyrus correlated positively with performance on the measure of complex abstraction. This feasibility study provides promising evidence that short-term reasoning training can enhance cognitive performance and brain health in adults with BD. These data motivate further efforts to explore adjuvant therapeutics to improve cognitive performance and underlying brain systems in bipolar, as well as other psychiatric disorders.en_US
dc.description.sponsorshipDunlap family grant (#20249169)en_US
dc.identifier.bibliographicCitationVenza, E., S. Chapman, A. Sina, J. Zientz, D. Tyler, J. Spence 2016. "Enhancing executive function and neural health in bipolar disorder through reasoning training." Frontiers in Psychology 7, doi: 10.3389/fpsyg.2016.01676en_US
dc.identifier.issn1664-1078en_US
dc.identifier.urihttp://hdl.handle.net/10735.1/5606
dc.identifier.volume7en_US
dc.publisherFrontiers Research Foundationen_US
dc.relation.urihttp://dx.doi.org/10.3389/fpsyg.2016.01676en_US
dc.rightsCC BY 4.0 (Attribution)en_US
dc.rights©2016 The Authors. All Rights Reserved.en_US
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en_US
dc.source.journalFrontiers in Psychologyen_US
dc.subjectManic-depressive illnessen_US
dc.subjectCerebral circulationen_US
dc.subjectCognitionen_US
dc.subjectCognitive therapyen_US
dc.subjectExecutive functions (Neuropsychology)en_US
dc.subjectNeural networks (Neurobiology)en_US
dc.titleEnhancing Executive Function and Neural Health in Bipolar Disorder Through Reasoning Trainingen_US
dc.typeTexten_US
dc.type.genrearticleen_US

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