Haptic Stroke Testbed for Pharmacological Evaluation of Dynamic Allodynia in Mouse Models

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dc.contributor.authorLee, Jin
dc.contributor.authorAtwood, Brian J.
dc.contributor.authorMegat, Salim
dc.contributor.authorDussor, Gregory
dc.contributor.authorPrice, Theodore J.
dc.contributor.authorFey, Ann Majewicz
dc.contributor.utdAuthorLee, Jin
dc.contributor.utdAuthorAtwood, Brian J.
dc.contributor.utdAuthorMegat, Salim
dc.contributor.utdAuthorDussor, Gregory
dc.contributor.utdAuthorPrice, Theodore J.
dc.contributor.utdAuthorFey, Ann Majewicz
dc.date.accessioned2019-07-26T17:07:30Z
dc.date.available2019-07-26T17:07:30Z
dc.date.created2018-03-25
dc.descriptionFull text access from Treasures at UT Dallas is restricted to current UTD affiliates (use the provided Link to Article).
dc.description.abstractDynamic mechanical allodynia is an aggravating neuropathological condition in which light, physical touch leads to pain. Developing pharmaceutical agents to treat this condition requires extensive animal trials using a mouse model, and a laborious process of manually stroking inflicted mouse paws, with a brush or cotton swab, while recording responses to that stimulus. In this paper, we developed an autonomous testing mechanism to create repeatable stroking sensations for mice during dynamic allodynia testing. The chamber consists of a belt driven brush mechanism and light and dark chambers. Additionally, we conducted a human subjects study to determine the baseline variability in human-performed dynamic allodynia testing. Our tactile stoke display is capable of stroking a mouse paw between 1-5 mm/s with a repeatable force. In our human subject experiments, the user applied force ranged from 0.1-9.0 gF with a maximum standard deviation of 4.13 gF. In contrast, our device is capable of producing repeatable brush strokes at 0.69 gF (SD = 0.13 gF) and 1.78 gF (SD = 0.16 gF) for two brushes. Preliminary animal studies show that normal mice are not disturbed by the stroking sensation; however, mice afflicted with allodynia move away from it. On average the injured mice spent 90% of their time in a bright, adverse environment to avoid the brush, whereas normal mice only spent 40% of their time in the bright environment.
dc.description.departmentErik Jonsson School of Engineering and Computer Science
dc.description.departmentSchool of Behavioral and Brain Sciences
dc.identifier.bibliographicCitationLee, J., B. J. Atwood, S. Megat, G. Dussor, et al. 2018. "Haptic stroke testbed for pharmacological evaluation of dynamic allodynia in mouse models." International Symposium on Haptic Interfaces for Virtual Environment and Teleoperator Systems (HAPTICS): 235-240, doi:10.1109/HAPTICS.2018.8357182
dc.identifier.isbn9781538654248 (ISBN)
dc.identifier.urihttps://hdl.handle.net/10735.1/6732
dc.language.isoen
dc.publisherIEEE Computer Society
dc.relation.urihttp://dx.doi.org/10.1109/HAPTICS.2018.8357182
dc.rights©2018 IEEE
dc.source.journalInternational Symposium on Haptic Interfaces for Virtual Environment and Teleoperator Systems
dc.subjectDynamics
dc.subjectLaboratory animals
dc.subjectHuman body--Experiments
dc.subjectPharmaceutical industry
dc.subjectMammals
dc.subjectAllodynia
dc.subjectNervous system—Diseases
dc.titleHaptic Stroke Testbed for Pharmacological Evaluation of Dynamic Allodynia in Mouse Models
dc.type.genrearticle

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Fey, Ann Majewicz
Dussor, Gregory
Price, Theodore J.