Investigation of Sweat Biomarkers for Real-time Reporting of Infection and Inflammation Using Wearable Sweat Sensor
dc.contributor.advisor | Prasad, Shalini | |
dc.contributor.advisor | Bereg, Sergey | |
dc.contributor.committeeMember | Muthukumar, Sriram | |
dc.contributor.committeeMember | Sirsi, Shashank | |
dc.contributor.committeeMember | Khoubrouy, Soudeh | |
dc.creator | Jagannath, Badrinath | |
dc.date.accessioned | 2024-03-22T19:59:20Z | |
dc.date.available | 2024-03-22T19:59:20Z | |
dc.date.created | 2021-12 | |
dc.date.issued | December 2021 | |
dc.date.submitted | December 2021 | |
dc.date.updated | 2024-03-22T19:59:20Z | |
dc.description.abstract | Inflammatory biomarkers are modulated due to an infection or inflammatory trigger. Cytokines are inflammatory biomarkers that orchestrate the manifestation and progression of an infection/inflammatory event. Hence, non-invasive, real-time monitoring of cytokines can be pivotal in assessing the progression of infection/inflammatory event. However, real-time monitoring of biomarkers is not feasible with the current technology as most of them rely on blood-based detection. Continuous monitoring of host immune markers in sweat can aid in realtime monitoring of the immune status. This dissertation demonstrates a wearable SWEATSENSER device that can track the levels of immune cytokine markers in real-time from passively expressed sweat. The developed device is of a watch form-factor that can be worn on the arm to reliably track the biomarker response from low volumes of sweat (~1 μL) and the biomarker levels can be monitored in real-time. The developed SWEATSENSER device was validated for reliably reporting the levels of several cytokines and chemokines. Additionally, this work presents a thorough validation on the presence of certain critical infection and inflammatory markers such as interferon-inducible protein (IP-10) and tumor necrosis factor- related apoptosis-inducing ligand (TRAIL), C-reactive protein that make it feasible for using sweat as a biofluid for actively monitoring the health status. Additionally, human subject clinical studies demonstrate the feasibility of non-invasively tracking infections such as influenza from sweat. Such a wearable device can offer significant strides in improving prognosis and provide personalized therapeutic treatment for several inflammatory/infectious diseases. | |
dc.format.mimetype | application/pdf | |
dc.identifier.uri | ||
dc.identifier.uri | https://hdl.handle.net/10735.1/10086 | |
dc.language.iso | en | |
dc.subject | Engineering, Biomedical | |
dc.title | Investigation of Sweat Biomarkers for Real-time Reporting of Infection and Inflammation Using Wearable Sweat Sensor | |
dc.type | Thesis | |
dc.type.material | text | |
local.embargo.lift | 2023-12-01 | |
local.embargo.terms | 2023-12-01 | |
thesis.degree.college | School of Engineering and Computer Science | |
thesis.degree.department | Biomedical Engineering | |
thesis.degree.grantor | The University of Texas at Dallas | |
thesis.degree.name | PHD |
Files
Original bundle
1 - 1 of 1
Loading...
- Name:
- JAGANNATH-PRIMARY-2022-1.pdf
- Size:
- 5.35 MB
- Format:
- Adobe Portable Document Format