CLASP (Continuous Lifestyle Awareness Through Sweat Platform): A Novel Sensor for Simultaneous Detection of Alcohol and Glucose from Passive Perspired Sweat

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dc.contributor.authorBhide, Ashlesha
dc.contributor.authorMuthukumar, S.
dc.contributor.authorPrasad, Shalini
dc.contributor.utdAuthorBhide, Ashlesha
dc.contributor.utdAuthorPrasad, Shalini
dc.date.accessioned2019-06-28T15:52:12Z
dc.date.available2019-06-28T15:52:12Z
dc.date.created2018-06-30
dc.descriptionFull text access from Treasures at UT Dallas is restricted to current UTD affiliates.
dc.descriptionIncludes supplementary material
dc.description.abstractWearable- IOT based low- cost platforms can enable dynamic lifestyle monitoring through enabling promising and exciting opportunities for wellness and chronic- disease management in personalized environments. Diabetic and pre- diabetic populations can modulate their alcohol intake by tracking their glycemic content continuously to prevent health risks through these platforms. We demonstrate the first technological proof of a combinatorial biosensor for continuous, dynamic monitoring of alcohol and glucose in ultra- low volumes (1–5 µL) of passive perspired sweat towards developing a wearable- IOT based platform. Non-invasive biosensing in sweat is achieved by a unique gold- zinc oxide (ZnO) thin film electrode stack fabricated on a flexible substrate suitable for wearable applications. The active ZnO sensing region is immobilized with enzyme complexes specific for the detection of alcohol and glucose through non- faradaic electrochemical impedance spectroscopy (EIS) and chronoamperometry (CA). Biomolecular interactions occurring at the electrode- sweat interface are represented by the impedance and capacitive current changes in response to charge modulations arising in the double layer. We also report the detection of alcohol concentrations of 0.01–100 mg/dl and glucose concentrations of 0.01–50 mg/dl present in synthetic sweat and perspired human sweat. The limit of detection obtained for alcohol and glucose was found to be 0.1 mg/dl in perspired human sweat. Cross- reactivity studies revealed that glucose and alcohol did not show any signal response to cross- reactive molecules. Furthermore, the stable temporal response of the combinatorial biosensor on continuous exposure to passive perspired human sweat spiked with alcohol and glucose over a 120-min duration was demonstrated. © 2018 Elsevier B.V.
dc.description.departmentErik Jonsson School of Engineering and Computer Science
dc.description.sponsorshipNational Institute on Alcohol Abuse and Alcoholism of the National Institutes of Health (R43AA026114).
dc.identifier.bibliographicCitationBhide, A., S. Muthukumar, and S. Prasad. 2018. "CLASP (Continuous lifestyle awareness through sweat platform): A novel sensor for simultaneous detection of alcohol and glucose from passive perspired sweat." Biosensors And Bioelectronics 117: 537-545, doi:10.1016/j.bios.2018.06.065
dc.identifier.issn0956-5663
dc.identifier.urihttps://hdl.handle.net/10735.1/6620
dc.identifier.volume117
dc.language.isoen
dc.publisherElsevier Ltd
dc.relation.urihttp://dx.doi.org/10.1016/j.bios.2018.06.065
dc.rights©2018 Elsevier B.V.
dc.source.journalBiosensors and Bioelectronics
dc.subjectImpedance spectroscopy
dc.subjectPerspiration
dc.subjectBiosensors
dc.subjectElectrodes
dc.subjectGlucose
dc.subjectGold compounds
dc.subjectHealth risk assessment
dc.subjectSemiconductors
dc.subjectZinc oxide
dc.subjectBlood alcohol
dc.subjectChronic diseases--Treatment
dc.titleCLASP (Continuous Lifestyle Awareness Through Sweat Platform): A Novel Sensor for Simultaneous Detection of Alcohol and Glucose from Passive Perspired Sweat
dc.type.genrearticle

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