The Role of Relevant Peptides on the Sex-specific Nature of Migraine




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Migraine is considered to be both one of the most disabling and common disorders worldwide yet, migraine is both more common and disabling among women. While this disorder effects 2-3 times as many women as men across the globe the reasons for this disparity are not known. These data present new insights regarding how calcitonin gene-related peptide interacts with the predominantly female hormone prolactin to create female-specific hypersensitivity in rodent models of migraine. This sensitivity to dural CGRP is also contingent on the presence of ovarian secreted hormones, although it is not yet clear which are responsible for mediating this effect. While CGRP is likely in part responsible for the prevalence of migraine in women, in this dissertation we present evidence that dural amylin leads to hypersensitivity in males, but not in females. As such amylin may mediate migraine in males; however, ovariectomized females demonstrate more robust responses to dural amylin, than their male counterparts. This suggests that ovarian derived hormones may block responses to dural amylin. The data covered in this project may provide valuable information for the development of sex-specific migraine therapeutics.



Biology, Neuroscience