Pentagalloyl Glucose and Its Functional Role in Vascular Health: Biomechanics and Drug-Delivery Characteristics

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dc.contributor.authorPatnaik, Sourav S.
dc.contributor.authorSimionescu, Dan T.
dc.contributor.authorGoergen, Craig J.
dc.contributor.authorHoyt, Kenneth
dc.contributor.authorSirsi, Shashank
dc.contributor.authorFinol, Ender A.
dc.contributor.utdAuthorHoyt, Kenneth
dc.contributor.utdAuthorSirsi, Shashank
dc.date.accessioned2020-07-10T14:50:48Z
dc.date.available2020-07-10T14:50:48Z
dc.date.issued2018-10-08
dc.descriptionDue to copyright restrictions and/or publisher's policy full text access from Treasures at UT Dallas is limited to current UTD affiliates (use the provided Link to Article).
dc.description.abstractPentagalloyl glucose (PGG) is an elastin-stabilizing polyphenolic compound that has significant biomedical benefits, such as being a free radical sink, an anti-inflammatory agent, anti-diabetic agent, enzymatic resistant properties, etc. This review article focuses on the important benefits of PGG on vascular health, including its role in tissue mechanics, the different modes of pharmacological administration (e.g., oral, intravenous and endovascular route, intraperitoneal route, subcutaneous route, and nanoparticle based delivery and microbubble-based delivery), and its potential therapeutic role in vascular diseases such as abdominal aortic aneurysms (AAA). In particular, the use of PGG for AAA suppression and prevention has been demonstrated to be effective only in the calcium chloride rat AAA model. Therefore, in this critical review we address the challenges that lie ahead for the clinical translation of PGG as an AAA growth suppressor.
dc.description.departmentErik Jonsson School of Engineering and Computer Science
dc.description.sponsorshipAmerican Heart Association Award #16CSA28480006
dc.identifier.bibliographicCitationPatnaik, Sourav S., Dan T. Simionescu, Craig J. Goergen, Kenneth Hoyt, et al. 2019. "Pentagalloyl Glucose and Its Functional Role in Vascular Health: Biomechanics and Drug-Delivery Characteristics." Annals of Biomedical Engineering 47(1): 39-59.
dc.identifier.issn0090-6964
dc.identifier.issue1
dc.identifier.urihttp://dx.doi.org/10.1007/s10439-018-02145-5
dc.identifier.urihttps://hdl.handle.net/10735.1/8699
dc.identifier.volume47
dc.language.isoen
dc.publisherSpringer
dc.rights©2018 Biomedical Engineering Society
dc.source.journalAnnals of Biomedical Engineering
dc.subjectElastin
dc.subjectCollagen
dc.subjectDrug delivery systems
dc.subjectGlucose
dc.subjectUltrasound contrast media
dc.subjectDown-Regulation
dc.subjectTannins
dc.subjectNanoparticles
dc.subjectSalivary proteins
dc.subjectAbdominal aneurysm
dc.subject.meshPentagalloylglucose
dc.subject.meshAortic Aneurysm, Abdominal
dc.titlePentagalloyl Glucose and Its Functional Role in Vascular Health: Biomechanics and Drug-Delivery Characteristics
dc.type.genrearticle

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