Quantitative Combination of Natural Anti-Oxidants Prevents Metabolic Syndrome by Reducing Oxidative Stress

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dc.contributor.ISNI0000 0001 1707 1372 (Zhang, MQ)
dc.contributor.authorGao, Mingjingen_US
dc.contributor.authorZhao, Zhenen_US
dc.contributor.authorLv, Pengyuen_US
dc.contributor.authorLi, YuFangen_US
dc.contributor.authorGao, Juntaoen_US
dc.contributor.authorZhang, Michael Q.en_US
dc.contributor.authorZhao, Baoluen_US
dc.contributor.utdAuthorZhang, Michael Q.en_US
dc.date.accessioned2016-07-20T22:46:53Z
dc.date.available2016-07-20T22:46:53Z
dc.date.created2015-06-26en_US
dc.date.issued2015-06-26en_US
dc.descriptionIncludes supplementary materialen_US
dc.description.abstractInsulin resistance and abdominal obesity are present in the majority of people with the metabolic syndrome. Antioxidant therapy might be a useful strategy for type 2 diabetes and other insulin-resistant states. The combination of vitamin C (Vc) and vitamin E has synthetic scavenging effect on free radicals and inhibition effect on lipid peroxidation. However, there are few studies about how to define the best combination of more than three anti-oxidants as it is difficult or impossible to test the anti-oxidant effect of the combination of every concentration of each ingredient experimentally. Here we present a math model, which is based on the classical Hill equation to determine the best combination, called Fixed Dose Combination (FDC), of several natural anti-oxidants, including Vc, green tea polyphenols (GTP) and grape seed extract proanthocyanidin (GSEP). Then we investigated the effects of FDC on oxidative stress, blood glucose and serum lipid levels in cultured 3T3-L1 adipocytes, high fat diet (HFD)-fed rats which serve as obesity model, and KK-ay mice as diabetic model. The level of serum malondialdehyde (MDA) in the treated rats was studied and Hematoxylin-Eosin (HE) staining or Oil red slices of liver and adipose tissue in the rats were examined as well. FDC shows excellent antioxidant and anti-glycation activity by attenuating lipid peroxidation. FDC determined in this investigation can become a potential solution to reduce obesity, to improve insulin sensitivity and be beneficial for the treatment of fat and diabetic patients. It is the first time to use the math model to determine the best ratio of three anti-oxidants, which can save much more time and chemical materials than traditional experimental method. This quantitative method represents a potentially new and useful strategy to screen all possible combinations of many natural anti-oxidants, therefore may help develop novel therapeutics with the potential to ameliorate the worldwide metabolic abnormalities.en_US
dc.description.sponsorshipThis work is supported by National Key Basic Research Project (973 program, 2012CB316503) and the National Natural Science Foundation of China (Nos. 31361163004 and 91019016)en_US
dc.identifier.bibliographicCitationGao, Mingjing, Zhen Zhao, Pengyu Lv, YuFang Li, et al. 2015. "Quantitative combination of natural anti-oxidants prevents metabolic syndrome by reducing oxidative stress." Redox Biology 6, doi:10.1016/j.redox.2015.06.013.en_US
dc.identifier.issn2213-2317en_US
dc.identifier.urihttp://hdl.handle.net/10735.1/4954
dc.identifier.volume6en_US
dc.relation.urihttp://dx.doi.org/10.1016/j.redox.2015.06.013
dc.rightsCC BY-NC-ND 4.0/ (Attribution-NonCommercial-NoDerivatives)en_US
dc.rights©2015 The Authorsen_US
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/en_US
dc.sourceRedox Biology
dc.subjectInsulin Resistanceen_US
dc.subjectObesity, Abdominalen_US
dc.subjectAntioxidantsen_US
dc.subjectHill's equationen_US
dc.subjectDiet, High Faten_US
dc.subjectMiceen_US
dc.titleQuantitative Combination of Natural Anti-Oxidants Prevents Metabolic Syndrome by Reducing Oxidative Stressen_US
dc.type.genreArticleen_US

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Zhang, Michael Q.